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Details for messenger / hormone: annexin A2

EndoNet ID: ENH00468

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Synonyms

  • annexin A2
  • annexin II
  • ANXA2
  • lipocortin II
  • calpactin I heavy chain
  • chromobindin-8
  • p36
  • protein I
  • placental anticoagulant protein IV
  • PAP-IV
  • ANX2
  • AXII

General information

  • ANXA2 is an autocrine/paracrine factor that enhances osteoclast formation and bone resorption. [1]
  • Annexin A2 is an endogenous inhibitor of PCSK9 function. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    Annexin A2

    Sequence 
    STVHEILCK LSLEGDHST PPSAYGSVK 
AYTNFDAER DALNIETAI KTKGVDEVT 
IVNILTNRS NAQRQDIAF AYQRRTKKE 
LASALKSAL SGHLETVIL GLLKTPAQY 
DASELKASM KGLGTDEDS LIEIICSRT 
NQELQEINR VYKEMYKTD LEKDIISDT 
SGDFRKLMV ALAKGRRAE DGSVIDYEL 
IDQDARDLY DAGVKRKGT DVPKWISIM 
TERSVPHLQ KVFDRYKSY SPYDMLESI 
RKEVKGDLE NAFLNLVQC IQNKPLYFA 
DRLYDSMKG KGTRDKVLI RIMVSRSEV 
DMLKIRSEF KRKYGKSLY YYIQQDTKG 
DYQKALLYL CGGDD
    UniProt P07355

    Links to other resources

    UniProt P07355
    Ensembl ENST00000451270
    KEGG hsa:302

    • Anatomical structure: placenta

    • Anatomical structure: bone_marrow

    • Anatomical structure: osteoclast

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      Influenced by:

      • IGF-1R
        in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
        • Stimulation of insulin and IGF-1 receptors by insulin caused a temporary dissociation of annexin II from these receptors, which was accompanied by an increased amount of extracellular annexin II [3]
      • insulin receptor
        in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
        • Stimulation of insulin and IGF-1 receptors by insulin caused a temporary dissociation of annexin II from these receptors, which was accompanied by an increased amount of extracellular annexin II [3]

    Targets

    Cell
    No records found.
    Reference