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Details for messenger / hormone: nociceptin

EndoNet ID: ENH00474

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Synonyms

  • nociceptin
  • orphanin FQ
  • PPNOC

General information

  • Binds receptor OPRL1 and positively regulates pain response.
  • Nociceptin, the endogenous peptide ligand for opioid receptor like-1 (ORL1) receptor, has been implicated in the inflammation and pain in the skin. [1]
  • Nociceptin acts on ORL1 receptor on the keratinocytes to produce leukotriene B(4), which induces itch-associated responses in mice. [1]

Classification

Hormone function

  • CNS function
    • pain

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • opioid neuropeptides

      Composition

      nociceptin peptide

      Sequence
      FGGFTGARK SARKLANQ

      Links to other resources

      UniProt Q13519
      Ensembl ENST00000301908
      KEGG hsa:5368
      • Anatomical structure: spinal_cord

      • Anatomical structure: hypothalamus

      • Anatomical structure: brain_stem

      • Anatomical structure: prosencephalon

      Targets

      CellOPRL1
      amygdaloid body Present
      hippocampus Present
      hypothalamus Present
      isocortex Present
      spinal cord Present
      substantia nigra Present
      Reference