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Details for messenger / hormone: galectin-1

EndoNet ID: ENH00476

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Synonyms

  • galectin-1
  • 14 kDa laminin-binding protein
  • putative MAPK-activating protein PM12
  • lactose-binding lectin 1
  • galaptin
  • 14 kDa lectin
  • galectin 1
  • beta-galactosidase binding lectin
  • S-lac lectin 1
  • lectin galactoside-binding soluble 1
  • beta-galactoside-binding lectin L-14-I
  • Gal-1
  • HPL
  • HBL
  • putative MAPK-activating protein MP12
  • LGALS1

General information

  • Galectin-1 tends to display pro-apoptotic effects. [1]
  • Existing as dimers.
  • Galectin-1 kills immature thymocytes and activated peripheral T cells by binding to glycans on T cell glycoproteins including CD7, CD45, and CD43. [2]
  • Galectin-1 enhances the migratory capabilities of tumor astrocytes and, therefore, their biological aggressiveness. [3]
  • Galectin-1 has pro-apoptotic effect against T cells by binding to various cell surface receptors including CD7 and CD45. [1]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Links to other resources

    UniProt P09382
    Ensembl ENST00000215909
    KEGG hsa:3956
    • Anatomical structure: placenta

    • Anatomical structure: lung

    • Anatomical structure: spleen

    • Anatomical structure: skin

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: smooth_muscle

    • Anatomical structure: cardiac_myocyte

    • Anatomical structure: thymus

    • Anatomical structure: kidney

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: smooth_muscle

    • Anatomical structure: neuron

    • Anatomical structure: platelet

    • Anatomical structure: sinusoidal_endothelial_cell

      • Galectin-1, a lectin which is specifically expressed on LSEC in the liver is known to bind to and induce apoptosis in activated T cells. [4]
      • Strong staining in unstimulated LSEC and very strong staining in stimulated LSEC. [4]
    • Anatomical structure: cerebellum

    • Anatomical structure: spinal_cord

    Targets

    Reference