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Details for messenger / hormone: Wnt-4

EndoNet ID: ENH00482

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Synonyms

  • WNT4
  • protein Wnt-4
  • wingless-type MMTV integration site family member 4
  • wnt 4
  • Wnt-4

General information

  • Member of the Wnt5a class (cannot induce secondary body axis formation in Xenopus), which binds Fzd to activate heterotrimeric G proteins and increase intracellular calcium levels or induce Rho-dependent changes in the actin cytoskeleton. [1]
  • All Wnts contain 23-24 cysteine residues. [1]
  • Optimal Wnt signaling also requires association with glycosaminoglycans (e.g. heparin sulfate and chondroitin sulfate) in the extracellular matrix. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • Wnt family

      Composition

      Sequence 
      SNWLYLAKL SSVGSISEE ETCEKLKGL 
IQRQVQMCK RNLEVMDSV RRGAQLAIE 
ECQYQFRNR RWNCSTLDS LPVFGKVVT 
QGTREAAFV YAISSAGVA FAVTRACSS 
GELEKCGCD RTVHGVSPQ GFQWSGCSD 
NIAYGVAFS QSFVDVRER SKGASSSRA 
LMNLHNNEA GRKAILTHM RVECKCHGV 
SGSCEVKTC WRAVPPFRQ VGHALKEKF 
DGATEVEPR RVGSSRALV PRNAQFKPH 
TDEDLVYLE PSPDFCEQD MRSGVLGTR 
GRTCNKTSK AIDGCELLC CGRGFHTAQ 
VELAERCSC KFHWCCFVK CRQCQRLVE 
LHTCR

      Links to other resources

      UniProt P56705
      Ensembl ENST00000290167
      KEGG hsa:54361

      • Anatomical structure: osteoblast

      Targets

      Cell
      No records found.
      Reference