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Details for messenger / hormone: neuromedin B

EndoNet ID: ENH00496

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Synonyms

  • Neuromedin-B
  • neuromedin B
  • neuromedin B-32
  • NMB

General information

  • Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. [1]
  • Neuromedin B (NMB) is one of the bombesin (BN)-related peptides in mammals. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    Neuromedin B

    Sequence
    GNLWATGHF M
    UniProt P08949

    Neuromedin B-32

    Sequence
    APLSWDLPE PRSRASKIR VHSRGNLWA 
    TGHFM
    UniProt P08949

    Neuromedin B mature peptide

    Sequence
    APLSWDLPE PRSRASKIR VHSRGNLWA 
    TGHFMG

    Links to other resources

    UniProt P08949
    Ensembl ENST00000360476
    KEGG hsa:4828
    • Anatomical structure: hypothalamus

    • Anatomical structure: colon

    • Anatomical structure: large_intestine

    • Anatomical structure: lung

    • Anatomical structure: basophil_thyrotroph_cell_of_anterior_pituitary

      • The thyrotroph seems to be the cell responsible for neuromedin B synthesis, because in the rat pituitary the peptide was detected only in TSH cells. [3]

      Influenced by:

      • TRH-R
        in basophil_thyrotroph_cell_of_anterior_pituitary
        • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [3]

    Targets

    Cellneuromedin B receptor
    basophil thyrotroph cell of anterior pituitary Present
    Influences
    • TSH
    bronchial epithelial cell Present
    central nerve system element Present
    digestive system Present
    Phenotypes
    • induction of smooth muscle contraction
    Reference