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Details for messenger / hormone: WIF-1

EndoNet ID: ENH00497

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Synonyms

  • WIF-1
  • WIF 1
  • wnt inhibitory factor 1
  • wnt-inhibitory factor-1
  • WIF1

General information

  • Interactions between Wnts and frizzled receptors are inhibited by members of the secreted frizzled-related protein family and Wnt inhibitory factor 1. [1]
  • Wnt-inhibitory factor-1 is a secreted protein that binds to Wnt proteins and inhibits their activities. [2]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Wnt inhibitory factor-1 mature peptide

    Sequence 
    GPPQEESLY LWIDAHQAR VLIGFEEDI 
LIVSEGKMA PFTHDFRKA QQRMPAIPV 
NIHSMNFTW QAAGQAEYF YEFLSLRSL 
DKGIMADPT VNVPLLGTV PHKASVVQV 
GFPCLGKQD GVAAFEVDV IVMNSEGNT 
ILQTPQNAI FFKTCLQAE CPGGCRNGG 
FCNERRICE CPDGFHGPH CEKALCTPR 
CMNGGLCVT PGFCICPPG FYGVNCDKA 
NCSTTCFNG GTCFYPGKC ICPPGLEGE 
QCEISKCPQ PCRNGGKCI GKSKCKCSK 
GYQGDLCSK PVCEPGCGA HGTCHEPNK 
CQCQEGWHG RHCNKRYEA SLIHALRPA 
GAQLRQHTP SLKKAEERR DPPESNYIW

    Wnt inhibitory factor 1 chain

    Sequence 
    GPPQEESLY LWIDAHQAR VLIGFEEDI 
LIVSEGKMA PFTHDFRKA QQRMPAIPV 
NIHSMNFTW QAAGQAEYF YEFLSLRSL 
DKGIMADPT VNVPLLGTV PHKASVVQV 
GFPCLGKQD GVAAFEVDV IVMNSEGNT 
ILQTPQNAI FFKTCQQAE CPGGCRNGG 
FCNERRICE CPDGFHGPH CEKALCTPR 
CMNGGLCVT PGFCICPPG FYGVNCDKA 
NCSTTCFNG GTCFYPGKC ICPPGLEGE 
QCEISKCPQ PCRNGGKCI GKSKCKCSK 
GYQGDLCSK PVCEPGCGA HGTCHEPNK 
CQCQEGWHG RHCNKRYEA SLIHALRPA 
GAQLRQHTP SLKKAEERR DPPESNYIW
    UniProt Q9Y5W5

    Links to other resources

    UniProt Q9Y5W5
    Ensembl ENST00000286574
    KEGG hsa:11197

    • Anatomical structure: lung

    Targets

    Cell
    No records found.
    Reference