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Details for messenger / hormone: Dkk2

EndoNet ID: ENH00499

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Synonyms

  • Dkk2
  • dkk 2
  • Dkk-2
  • dickkopf 2
  • dickkopf-related protein 2
  • dickkopf-2
  • hDkk-2

General information

  • DKK2 is secreted as a 15- to 17-kD protein.
  • Dkk proteins compete for the Lrp5/6 receptor to prevent activation of the canonical signaling pathway. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Dickkopf homolog 2 mature peptide

    Sequence 
    KLNSIKSSL GGETPGQAA NRSAGMYQG 
LAFGGSKKG KNLGQAYPC SSDKECEVG 
RYCHSPHQG SSACMVCRR KKKRCHRDG 
MCCPSTRCN NGICIPVTE SILTPHIPA 
LDGTRHRDR NHGHYSNHD LGWQNLGRP 
HTKMSHIKG HEGDPCLRS SDCIEGFCC 
ARHFWTKIC KPVLHQGEV CTKQRKKGS 
HGLEIFQRC DCAKGLSCK VWKDATYSS 
KARLHVCQK I

    Dickkopf-related protein 2 chain

    Sequence 
    KLNSIKSSL GGETPGQAA NRSAGMYQG 
LAFGGSKKG KNLGQAYPC SSDKECEVG 
RYCHSPHQG SSACMVCRR KKKRCHRDG 
MCCPSTRCN NGICIPVTE SILTPHIPA 
LDGTRHRDR NHGHYSNHD LGWQNLGRP 
HTKMSHIKG HEGDPCLRS SDCIEGFCC 
ARHFWTKIC KPVLHQGEV CTKQRKKGS 
HGLEIFQRC DCAKGLSCK VWKDATYSS 
KARLHVCQK I
    UniProt Q9UBU2

    Links to other resources

    UniProt Q9UBU2
    Ensembl ENST00000285311
    KEGG hsa:27123

    • Anatomical structure: heart

    • Anatomical structure: brain

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: lung

    • Anatomical structure: brain

    • Anatomical structure: lung

    • Anatomical structure: heart

    • Anatomical structure: skeleton_muscle

    Targets

    Cellkremen 2
    brain Present
    uterus Present
    Reference