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Details for messenger / hormone: sFRP-2

EndoNet ID: ENH00504

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Synonyms

  • sFRP-2
  • secreted apoptosis-related protein 1
  • SFRP2
  • secreted frizzled-related protein 2
  • SARP1
  • SARP-1
  • frizzled-related protein 2
  • FRP-2
  • FRP2

General information

  • Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis. [1]
  • The secreted frizzled related protein 2 gene is a target of the Pax2 transcription factor. [2]
  • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. [3]

Classification

Hormone function

  • development and growth
    • apoptosis
      • embryogenesis

      Chemical classification

      • hormone
        • genome-encoded
          • frizzled family

        Composition

        Secreted frizzled-related protein 2 mature peptide

        Sequence 
        GSARGLFLF GQPDFSYKR SNCKPIPAN 
LQLCHGIEY QNMRLPNLL GHETMKEVL 
EQAGAWIPL VMKQCHPDT KKFLCSLFA 
PVCLDDLDE TIQPCHSLC VQVKDRCAP 
VMSAFGFPW PDMLECDRF PQDNDLCIP 
LASSDHLLP ATEEAPKVC EACKNKNDD 
DNDIMETLC KNDFALKIK VKEITYINR 
DTKIILETK SKTIYKLNG VSERDLKKS 
VLWLKDSLQ CTCEEMNDI NAPYLVMGQ 
KQGGELVIT SVKRWQKGQ REFKRISRS 
IRKLQC

        Links to other resources

        UniProt Q96HF1
        Ensembl ENST00000274063
        KEGG hsa:6423

        • Anatomical structure: adipose_tissue

        • Anatomical structure: eye

        • Anatomical structure: heart

        • Anatomical structure: brain

        • Anatomical structure: skeleton_muscle

        • Anatomical structure: pancreas

        • Anatomical structure: thymus

        • Anatomical structure: prostate

        • Anatomical structure: testis

        • Anatomical structure: ovary

        • Anatomical structure: small_intestine

        • Anatomical structure: colon

        • Anatomical structure: osteoblast

        Targets

        Cell
        No records found.
        Reference