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Details for messenger / hormone: sclerostin

EndoNet ID: ENH00507

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Synonyms

  • sclerosteosis
  • sclerostin
  • SOST
  • VBCH

General information

  • Increased bone density in sclerosteosis is due to the deficiency of the secreted protein SOST. [1]
  • Osteocyte control of bone formation happens via sclerostin, a novel BMP antagonist. [2]
  • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. [3]
  • Noggin and sclerostin are bone morphogenetic protein (BMP) antagonists that modulate mitogenic activity through sequestering BMPs. [4]
  • Sclerostin plays an important role in bone remodeling and links bone resorption and bone apposition. [5]
  • Sclerostin promotes the apoptosis of human osteoblastic cells. [6]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • apoptosis
        • embryogenesis

        Chemical classification

        Composition

        Sclerostin isoform 1 chain

        Sequence 
        QGWQAFKND ATEIIPELG EYPEPPPEL 
ENNKTMNRA ENGGRPPHH PFETKDVSE 
YSCRELHFT RYVTDGPCR SAKPVTELV 
CSGQCGPAR LLPNAIGRG KWWRPSGPD 
FRCIPDRYR AQRVQLLCP GGEAPRARK 
VRLVASCKC KRLTRFHNQ SELKDFGTE 
AARPQKGRK PRPRARSAK ANQAELENA 
Y
        UniProt Q9BQB4-1

        Sclerostin isoform 2

        Sequence 
        MQLPLALCL VCLLVHTAF RVVEGQGWQ 
AFKNDATEI IPELGEYPE PPPELENNK 
TMNRAENGG WPGGRPPSR APLSTDVSE 
YSCRELHFT RYVTDGPCR SAKPVTELV 
CSGQCGPAR LLPNAIGRG KWWRPSGPD 
FRCIPDRYR AQRVQLLCP GGEAPRARK 
VRLVASCKC KRLTRFHNQ SELKDFGTE 
AARPQKGRK PRPRARSAK ANQAELENA 
Y
        UniProt Q9BQB4-2

        sclerostin mature peptide

        Sequence 
        QGWQAFKND ATEIIPELG EYPEPPPEL 
ENNKTMNRA ENGGRPPHH PFETKDVSE 
YSCRELHFT RYVTDGPCR SAKPVTELV 
CSGQCGPAR LLPNAIGRG KWWRPSGPD 
FRCIPDRYR AQRVQLLCP GGEAPRARK 
VRLVASCKC KRLTRFHNQ SELKDFGTE 
AARPQKGRK PRPRARSAK ANQAELENA 
Y

        Links to other resources

        UniProt Q9BQB4
        Ensembl ENST00000301691
        KEGG hsa:50964

        • Anatomical structure: bone_marrow

        • Anatomical structure: cartilage

        • Anatomical structure: kidney

        • Anatomical structure: osteoblast

        • Anatomical structure: bone

        • Anatomical structure: heart

        • Anatomical structure: lung

        • Anatomical structure: pancreas

        • Anatomical structure: osteoblast

        • Anatomical structure: osteocyte

        Targets

        CellLRP5LRP6
        adrenal cortex Present
        beta cell of islet of Langerhans Present
        hepatocyte Present
        kidney Present
        Kupffer cell stellate cell of liver Present
        lipocyte of liver Present
        Phenotypes
        • positive regulation of cell-matrix adhesion
        macrophage Present
        osteoblast Present
        Reference