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Details for messenger / hormone: norrin

EndoNet ID: ENH00528

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Synonyms

  • exudative vitreoretinopathy 2 (X-linked)
  • X-linked exudative vitreoretinopathy 2 protein
  • norrin
  • norrie disease protein
  • NDP
  • norrie disease
  • norrie disease homolog
  • ND

General information

  • Norrin is a secretory protein containing a cysteine-knot motif and a high-affinity ligand for Fz4. [1]
  • Norrin is a secreted protein that forms disulfide-bonded oligomers that are associated with the extracellular matrix upon secretion from cells. [2]
  • Similar to Wnt, Norrin bound to LRP and Frizzled can stimulate the canonical signaling pathway. [3]
  • The Norrin-Fz4 signaling system plays a central role in vascular development in the eye and ear. [4]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    Norrin

    Sequence
    KTDSSFIMD SDPRRCMRH HYVDSISHP 
    LYKCSSKMV LLARCEGHC SQASRSEPL 
    VSFSTVLKQ PFRSSCHCC RPQTSKLKA 
    LRLRCSGGM RLTATYRYI LSCHCEECN 
    S
    UniProt Q00604

    Links to other resources

    UniProt Q00604
    Ensembl ENST00000378062
    KEGG hsa:4693
    • Anatomical structure: retina

    • Anatomical structure: hippocampus

    • Anatomical structure: brain_stem

    Targets

    Cellfrizzled 4LRP5
    adrenal cortex Present
    beta cell of islet of Langerhans Present
    hepatocyte Present
    kidney Present
    Kupffer cell stellate cell of liver Present
    lipocyte of liver Present
    Phenotypes
    • positive regulation of cell-matrix adhesion
    macrophage Present
    osteoblast Present
    Reference