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Details for messenger / hormone: PYY (1-36)

EndoNet ID: ENH00539

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Synonyms

  • PYY-II
  • PYY (1-36)
  • peptide YY
  • peptide tyrosine tyrosine
  • PYY-I

General information

  • Peptide YY and neuropeptide Y, both members of the pancreatic polypeptide family, can be processed by dipeptidyl peptidase IV to their (3-36) fragments by removal of the N-terminal Tyr-Pro dipeptide, which generates a metabolite of different receptor selectivity. [1]
  • PYY(1-36) stimulates appetite and weight gain through Y1 and Y5 receptors. [2]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • NPY family

      Composition

      Sequence
      YPIKPEAPG EDASPEELN RYYASLRHY 
      LNLVTRQRY

      Links to other resources

      UniProt P10082
      Ensembl ENST00000360085
      KEGG hsa:5697
      • Anatomical structure: colon

      Targets

      CellNPY1-RNPY2-RNPY4-RNPY5-R
      amygdaloid body Present
      Present
      arcuate nucleus of hypothalamus Present
      Phenotypes
      • positive regulation of appetite
      Present
      Phenotypes
      • negative regulation of appetite
      • positive regulation of appetite
      Influences
      • NPY
      • AGRP
      Present
      Phenotypes
      • positive regulation of appetite
      Present
      Phenotypes
      • positive regulation of appetite
      Influences
      • GnRH-I
      blood vessel Present
      caudate nucleus Present
      colon Present
      corpus callosum Present
      hippocampus Present
      hypothalamus Present
      Influences
      • NPY
      Present
      ileum Present
      kidney Present
      left coronary artery Present
      osteoblast Present
      pancreas Present
      right coronary artery Present
      small intestine Present
      smooth muscle Present
      substantia nigra Present
      subthalamic nucleus Present
      Reference