Status
Please wait ...

Details for messenger / hormone: PYY(3-36)

EndoNet ID: ENH00540

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • peptide tyrosine tyrosine
  • PYY-I
  • peptide YY
  • PYY(3-36)
  • peptide YY(3-36)
  • PYY-II

General information

  • Peptide YY(3-36), a Y2R agonist, is released from the gastrointestinal tract postprandially in proportion to the calorie content of a meal. [1]
  • PYY(3-36) suppresses appetite and stimulates weight loss through Y2 receptors. [2]
  • Peptide YY and neuropeptide Y, both members of the pancreatic polypeptide family, can be processed by dipeptidyl peptidase IV to their (3-36) fragments by removal of the N-terminal Tyr-Pro dipeptide, which generates a metabolite of different receptor selectivity. [3]
  • Released in response to food intake. [4]
  • Plasma PYY concentrations are increased by insulin-like growth factor-1, bombesin, and calcitonin gene-related peptide and decreased by GLP-1. [4]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • NPY family

      Composition

      Sequence
      IKPEAPGED ASPEELNRY YASLRHYLN 
      LVTRQRY

      Links to other resources

      UniProt P10082
      Ensembl ENST00000360085
      KEGG hsa:5697
      • Anatomical structure: digestive_system

        • It is secreted in the L-cells of the gastrointestinal tract after nutrition uptake [5]

      Targets

      CellNPY2-RNPY4-RNPY5-R
      amygdaloid body Present
      Present
      arcuate nucleus of hypothalamus Present
      Phenotypes
      • negative regulation of appetite
      • positive regulation of appetite
      Influences
      • NPY
      • AGRP
      Present
      Phenotypes
      • positive regulation of appetite
      Present
      Phenotypes
      • positive regulation of appetite
      Influences
      • GnRH-I
      blood vessel Present
      caudate nucleus Present
      colon Present
      corpus callosum Present
      hippocampus Present
      hypothalamus Present
      Influences
      • NPY
      Present
      ileum Present
      kidney Present
      left coronary artery Present
      pancreas Present
      right coronary artery Present
      small intestine Present
      smooth muscle Present
      substantia nigra Present
      subthalamic nucleus Present
      Reference