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Details for messenger / hormone: TNFSF18

EndoNet ID: ENH00541

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Synonyms

  • TNFSF18
  • tumor necrosis factor ligand superfamily member 18
  • glucocorticoid-induced TNF-related ligand
  • AITRL
  • activation-inducible TNF-related ligand

General information

  • Important for interactions between activated T-lymphocytes and endothelial cells. [1]
  • Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TNF family

      Composition

      Subunit (3 times)

      Sequence 
      MCLSHLENM PLSHSRTQG AQRSSWKLW 
LFCSIVMLL FLCSFSWLI FIFLQLETA 
KEPCMAKFG PLPSKWQMA SSEPPCVNK 
VSDWKLEIL QNGLYLIYG QVAPNANYN 
DVAPFEVRL YKNKDMIQT LTNKSKIQN 
VGGTYELHV GDTIDLIFN SEHQVLKNN 
TYWGIILLA NPQFIS

      Links to other resources

      UniProt Q9UNG2
      Ensembl ENST00000404377
      KEGG hsa:8995

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: kidney

      • Anatomical structure: ovary

      • Anatomical structure: small_intestine

      • Anatomical structure: testis

      Targets

      CellTNFRSF18 isoform 1
      lymph node Present
      Phenotypes
      • leukocyte migration
      spleen Present
      Phenotypes
      • negative regulation of lymphocyte apoptosis
      Reference