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Details for messenger / hormone: APOA1

EndoNet ID: ENH00542

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Synonyms

  • APOA1
  • ApoA-I
  • Apo-AI
  • apolipoprotein A-I
  • apolipoprotein A1
  • apolipoprotein-A1

General information

  • Apolipoprotein-A1 is downregulated in ovarian cancer sera, and could therefore be used as marker. [1]
  • Apolipoprotein A-I (apoA-I) is the major apolipoprotein of high-density lipoproteins (HDL) and has an important role in the regulation of the stability, lipid transport, and metabolism of HDL particles. [2]
  • A low dose infusion of ApoA-I inhibits neutrophil and endothelial cell activation in carotid arteries decreases neutrophil infiltration. [3]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      apolipoprotein A-I

      Sequence 
      DEPPQSPWD RVKDLATVY VDVLKDSGR 
DYVSQFEGS ALGKQLNLK LLDNWDSVT 
STFSKLREQ LGPVTQEFW DNLEKETEG 
LRQEMSKDL EEVKAKVQP YLDDFQKKW 
QEEMELYRQ KVEPLRAEL QEGARQKLH 
ELQEKLSPL GEEMRDRAR AHVDALRTH 
LAPYSDELR QRLAARLEA LKENGGARL 
AEYHAKATE HLSTLSEKA KPALEDLRQ 
GLLPVLESF KVSFLSALE EYTKKLNTQ

      Links to other resources

      UniProt P02647
      Ensembl ENST00000375329
      KEGG hsa:335

      • Anatomical structure: hepatocyte

      • Anatomical structure: small_intestine

      Targets

      Reference