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Details for messenger / hormone: apolipoprotein A-II

EndoNet ID: ENH00545

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Synonyms

  • apolipoprotein A2
  • apolipoprotein A-II
  • ApoA-II
  • Apo-AII

General information

  • Apoöipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. [1]
  • Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties. [2]
  • Function: secreted by liver and small intestine, it plays a key role in the formation, metabolism and catabolism of HDL. [3]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      truncated apolipoprotein A-II

      Sequence 
      QAKEPCVES LVSQYFQTV TDYGKDLME 
KVKSPELQA EAKSYFEKS KEQLTPLIK 
KAGTELVNF LSYFVELGT QPAT

      Apolipoprotein A-II

      Sequence 
      QAKEPCVES LVSQYFQTV TDYGKDLME 
KVKSPELQA EAKSYFEKS KEQLTPLIK 
KAGTELVNF LSYFVELGT QPATQ

      Links to other resources

      UniProt P02652
      Ensembl ENST00000367990
      KEGG hsa:336

      • Anatomical structure: hepatocyte

      Targets

      CellSR-BI
      hepatocyte Present
      Reference