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Details for messenger / hormone: apo B-100

EndoNet ID: ENH00548

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Synonyms

  • apo B-100
  • apolipoprotein B-100
  • apolipoprotein B100
  • apo B100
  • ApoB-100
  • ApoB100

General information

  • The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL. [1]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      apolipoprotein B-100

      Sequence
      EEEMLENVS LVCPKDATR FKHLRKYTY 
      NYEAESSSG VPGTADSRS ATRINCKVE 
      LEVPQLCSF ILKTSQCTL KEVYGFNPE 
      GKALLKKTK NSEEFAAAM SRYELKLAI 
      PEGKQVFLY PEKDEPTYI LNIKRGIIS 
      ALLVPPETE EAKQVLFLD TVYGNCSTH 
      FTVKTRKGN VATEISTER DLGQCDRFK 
      PIRTGISPL ALIKGMTRP LSTLISSSQ 
      SCQYTLDAK RKHVAEAIC KEQHLFLPF 
      SYNNKYGMV AQVTQTLKL EDTPKINSR 
      FFGEGTKKM GLAFESTKS TSPPKQAEA 
      VLKTLQELK KLTISEQNI QRANLFNKL 
      VTELRGLSD EAVTSLLPQ LIEVSSPIT 
      LQALVQCGQ PQCSTHILQ WLKRVHANP 
      LLIDVVTYL VALIPEPSA QQLREIFNM 
      ARDQRSRAT LYALSHAVN NYHKTNPTG 
      TQELLDIAN YLMEQIQDD CTGDEDYTY 
      LILRVIGNM GQTMEQLTP ELKSSILKC 
      VQSTKPSLM IQKAAIQAL RKMEPKDKD 
      QEVLLQTFL DDASPGDKR LAAYLMLMR 
      SPSQADINK IVQILPWEQ NEQVKNFVA 
      SHIANILNS EELDIQDLK KLVKEALKE 
      SQLPTVMDF RKFSRNYQL YKSVSLPSL 
      DPASAKIEG NLIFDPNNY LPKESMLKT 
      TLTAFGFAS ADLIEIGLE GKGFEPTLE 
      ALFGKQGFF PDSVNKALY WVNGQVPDG 
      VSKVLVDHF GYTKDDKHE QDMVNGIML 
      SVEKLIKDL KSKEVPEAR AYLRILGEE 
      LGFASLHDL QLLGKLLLM GARTLQGIP 
      QMIGEVIRK GSKNDFFLH YIFMENAFE 
      LPTGAGLQL QISSSGVIA PGAKAGVKL 
      EVANMQAEL VAKPSVSVE FVTNMGIII 
      PDFARSGVQ MNTNFFHES GLEAHVALK 
      AGKLKFIIP SPKRPVKLL SGGNTLHLV 
      STTKTEVIP PLIENRQSW SVCKQVFPG 
      LNYCTSGAY SNASSTDSA SYYPLTGDT 
      RLELELRPT GEIEQYSVS ATYELQRED 
      RALVDTLKF VTQAEGAKQ TEATMTFKY 
      NRQSMTLSS EVQIPDFDV DLGTILRVN 
      DESTEGKTS YRLTLDIQN KKITEVALM 
      GHLSCDTKE ERKIKGVIS IPRLQAEAR 
      SEILAHWSP AKLLLQMDS SATAYGSTV 
      SKRVAWHYD EEKIEFEWN TGTNVDTKK 
      MTSNFPVDL SDYPKSLHM YANRLLDHR 
      VPETDMTFR HVGSKLIVA MSSWLQKAS 
      GSLPYTQTL QDHLNSLKE FNLQNMGLP 
      DFHIPENLF LKSDGRVKY TLNKNSLKI 
      EIPLPFGGK SSRDLKMLE TVRTPALHF 
      KSVGFHLPS REFQVPTFT IPKLYQLQV 
      PLLGVLDLS TNVYSNLYN WSASYSGGN 
      TSTDHFSLR ARYHMKADS VVDLLSYNV 
      QGSGETTYD HKNTFTLSC DGSLRHKFL 
      DSNIKFSHV EKLGNNPVS KGLLIFDAS 
      SSWGPQMSA SVHLDSKKK QHLFVKEVK 
      IDGQFRVSS FYAKGTYGL SCQRDPNTG 
      RLNGESNLR FNSSYLQGT NQITGRYED 
      GTLSLTSTS DLQSGIIKN TASLKYENY 
      ELTLKSDTN GKYKNFATS NKMDMTFSK 
      QNALLRSEY QADYESLRF FSLLSGSLN 
      SHGLELNAD ILGTDKINS GAHKATLRI 
      GQDGISTSA TTNLKCSLL VLENELNAE 
      LGLSGASMK LTTNGRFRE HNAKFSLDG 
      KAALTELSL GSAYQAMIL GVDSKNIFN 
      FKVSQEGLK LSNDMMGSY AEMKFDHTN 
      SLNIAGLSL DFSSKLDNI YSSDKFYKQ 
      TVNLQLQPY SLVTTLNSD LKYNALDLT 
      NNGKLRLEP LKLHVAGNL KGAYQNNEI 
      KHIYAISSA ALSASYKAD TVAKVQGVE 
      FSHRLNTDI AGLASAIDM STNYNSDSL 
      HFSNVFRSV MAPFTMTID AHTNGNGKL 
      ALWGEHTGQ LYSKFLLKA EPLAFTFSH 
      DYKGSTSHH LVSRKSISA ALEHKVSAL 
      LTPAEQTGT WKLKTQFNN NEYSQDLDA 
      YNTKDKIGV ELTGRTLAD LTLLDSPIK 
      VPLLLSEPI NIIDALEMR DAVEKPQEF 
      TIVAFVKYD KNQDVHSIN LPFFETLQE 
      YFERNRQTI IVVVENVQR NLKHINIDQ 
      FVRKYRAAL GKLPQQAND YLNSFNWER 
      QVSHAKEKL TALTKKYRI TENDIQIAL 
      DDAKINFNE KLSQLQTYM IQFDQYIKD 
      SYDLHDLKI AIANIIDEI IEKLKSLDE 
      HYHIRVNLV KTIHDLHLF IENIDFNKS 
      GSSTASWIQ NVDTKYQIR IQIQEKLQQ 
      LKRHIQNID IQHLAGKLK QHIEAIDVR 
      VLLDQLGTT ISFERINDV LEHVKHFVI 
      NLIGDFEVA EKINAFRAK VHELIERYE 
      VDQQIQVLM DKLVELTHQ YKLKETIQK 
      LSNVLQQVK IKDYFEKLV GFIDDAVKK 
      LNELSFKTF IEDVNKFLD MLIKKLKSF 
      DYHQFVDET NDKIREVTQ RLNGEIQAL 
      ELPQKAEAL KLFLEETKA TVAVYLESL 
      QDTKITLII NWLQEALSS ASLAHMKAK 
      FRETLEDTR DRMYQMDIQ QELQRYLSL 
      VGQVYSTLV TYISDWWTL AAKNLTDFA 
      EQYSIQDWA KRMKALVEQ GFTVPEIKT 
      ILGTMPAFE VSLQALQKA TFQTPDFIV 
      PLTDLRIPS VQINFKDLK NIKIPSRFS 
      TPEFTILNT FHIPSFTID FVEMKVKII 
      RTIDQMQNS ELQWPVPDI YLRDLKVED 
      IPLARITLP DFRLPEIAI PEFIIPTLN 
      LNDFQVPDL HIPEFQLPH ISHTIEVPT 
      FGKLYSILK IQSPLFTLD ANADIGNGT 
      TSANEAGIA ASITAKGES KLEVLNFDF 
      QANAQLSNP KINPLALKE SVKFSSKYL 
      RTEHGSEML FFGNAIEGK SNTVASLHT 
      EKNTLELSN GVIVKINNQ LTLDSNTKY 
      FHKLNIPKL DFSSQADLR NEIKTLLKA 
      GHIAWTSSG KGSWKWACP RFSDEGTHE 
      SQISFTIEG PLTSFGLSN KINSKHLRV 
      NQNLVYESG SLNFSKLEI QSQVDSQHV 
      GHSVLTAKG MALFGEGKA EFTGRHDAH 
      LNGKVIGTL KNSLFFSAQ PFEITASTN 
      NEGNLKVRF PLRLTGKID FLNNYALFL 
      SPSAQQASW QVSARFNQY KYNQNFSAG 
      NNENIMEAH VGINGEANL DFLNIPLTI 
      PEMRLPYTI ITTPPLKDF SLWEKTGLK 
      EFLKTTKQS FDLSVKAQY KKNKHRHSI 
      TNPLAVLCE FISQSIKSF DRHFEKNRN 
      NALDFVTKS YNETKIKFD KYKAEKSHD 
      ELPRTFQIP GYTVPVVNV EVSPFTIEM 
      SAFGYVFPK AVSMPSFSI LGSDVRVPS 
      YTLILPSLE LPVLHVPRN LKLSLPHFK 
      ELCTISHIF IPAMGNITY DFSFKSSVI 
      TLNTNAELF NQSDIVAHL LSSSSSVID 
      ALQYKLEGT TRLTRKRGL KLATALSLS 
      NKFVEGSHN STVSLTTKN MEVSVAKTT 
      KAEIPILRM NFKQELNGN TKSKPTVSS 
      SMEFKYDFN SSMLYSTAK GAVDHKLSL 
      ESLTSYFSI ESSTKGDVK GSVLSREYS 
      GTIASEANT YLNSKSTRS SVKLQGTSK 
      IDDIWNLEV KENFAGEAT LQRIYSLWE 
      HSTKNHLQL EGLFFTNGE HTSKATLEL 
      SPWQMSALV QVHASQPSS FHDFPDLGQ 
      EVALNANTK NQKIRWKNE VRIHSGSFQ 
      SQVELSNDQ EKAHLDIAG SLEGHLRFL 
      KNIILPVYD KSLWDFLKL DVTTSIGRR 
      QHLRVSTAF VYTKNPNGY SFSIPVKVL 
      ADKFITPGL KLNDLNSVL VMPTFHVPF 
      TDLQVPSCK LDFREIQIY KKLRTSSFA 
      LNLPTLPEV KFPEVDVLT KYSQPEDSL 
      IPFFEITVP ESQLTVSQF TLPKSVSDG 
      IAALDLNAV ANKIADFEL PTIIVPEQT 
      IEIPSIKFS VPAGIVIPS FQALTARFE 
      VDSPVYNAT WSASLKNKA DYVETVLDS 
      TCSSTVQFL EYELNVLGT HKIEDGTLA 
      SKTKGTLAH RDFSAEYEE DGKFEGLQE 
      WEGKAHLNI KSPAFTDLH LRYQKDKKG 
      ISTSAASPA VGTVGMDMD EDDDFSKWN 
      FYYSPQSSP DKKLTIFKT ELRVRESDE 
      ETQIKVNWE EEAASGLLT SLKDNVPKA 
      TGVLYDYVN KYHWEHTGL TLREVSSKL 
      RRNLQNNAE WVYQGAIRQ IDDIDVRFQ 
      KAASGTTGT YQEWKDKAQ NLYQELLTQ 
      EGQASFQGL KDNVFDGLV RVTQKFHMK 
      VKHLIDSLI DFLNFPRFQ FPGKPGIYT 
      REELCTMFI REVGTVLSQ VYSKVHNGS 
      EILFSYFQD LVITLPFEL RKHKLIDVI 
      SMYRELLKD LSKEAQEVF KAIQSLKTT 
      EVLRNLQDL LQFIFQLIE DNIKQLKEM 
      KFTYLINYI QDEINTIFN DYIPYVFKL 
      LKENLCLNL HKFNEFIQN ELQEASQEL 
      QQIHQYIMA LREEYFDPS IVGWTVKYY 
      ELEEKIVSL IKNLLVALK DFHSEYIVS 
      ASNFTSQLS SQVEQFLHR NIQEYLSIL 
      TDPDGKGKE KIAELSATA QEIIKSQAI 
      ATKKIISDY HQQFRYKLQ DFSDQLSDY 
      YEKFIAESK RLIDLSIQN YHTFLIYIT 
      ELLKKLQST TVMNPYMKL APGELTIIL

      Links to other resources

      UniProt P04114
      Ensembl ENST00000233242
      KEGG hsa:338
      • Anatomical structure: hepatocyte

        Influenced by:

        • LDL-R
          in hepatocyte
          • Apolipoprotein B (apoB) is required for the hepatic assembly and secretion of very low density lipoprotein (VLDL). The LDL receptor (LDLR) promotes post-translational degradation of apoB and thereby reduces VLDL particle secretion. [2]
          • LDLR directs apoB to degradation in a post-ER compartment. Furthermore, the reuptake mechanism of degradation occurs via internalization of apoB through a constitutive endocytic pathway and apoE through a ligand-dependent pathway. [2]
        • Sterol O-acyltransferase 1
          in hepatocyte
          • Cholesteryl esters play an important role in regulating the assembly and secretion of apoB-containing lipoproteins. [3]
        • PPAR-alpha
          in hepatocyte
          • The peroxisome proliferator-activated receptor (PPAR) agonist WY 14,643 increased the secretion of apolipoprotein (apo) B-100, but not that of apoB-48, and decreased triglyceride biosynthesis and secretion from primary rat hepatocytes. These effects resulted in decreased secretion of apoB-100-very low density lipoprotein (VLDL) and an increased secretion of apoB-100 on low density lipoproteins/intermediate density lipoproteins. [4]
        • autocrine motility factor receptor
          in hepatocyte
          • Tumor autocrine motility factor receptor, also known as gp78, is an endoplasmic reticulum (ER)-associated E3. This E3 is involved in the ER-associated degradation of nascent apoB. [5]

      Targets

      Cellthrombospondin receptor
      adipose tissue Present
      Phenotypes
      • transport of long-chain fatty acids
      blood vessel Present
      bone marrow Present
      cell of endometrium of uterus Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • negative regulation of angiogenesis
      cytotrophoblast Present
      fat cell Present
      Phenotypes
      • transport of long-chain fatty acids
      monocyte Present
      Phenotypes
      • positive regulation of macrophage derived foam cell
      placenta Present
      platelet Present
      Phenotypes
      • regulation of cell adhesion
      skeleton muscle Present
      Phenotypes
      • lipid homeostasis
      Reference