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Details for messenger / hormone: APOC1

EndoNet ID: ENH00550

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Synonyms

  • apolipoprotein C1
  • apolipoprotein C-I
  • APOC1
  • ApoC-I
  • Apo-CI
  • ApoC-1
  • apolipoprotein C-1
  • apolipoproteinC-1

General information

  • Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase. [1]
  • APOC-I binds the free fatty acid (FFA) in the circulation, thereby reducing the availability of FFA for uptake by cells. [2]
  • Mature human apolipoprotein C-I), comprising 57 amino acids, is the smallest member of the plasma apolipoprotein family. Amphipathic helical regions within apoC-I, common to this class of proteins, are mediators of lipid binding, a process that underlies the functional properties of apoC-I, including the capacity to activate the plasma enzyme LCAT, to disrupt apoE mediated receptor interactions and to inhibit cholesterol ester transfer protein. [3]
  • APOC-I is expressed in the liver and in macrophages, and has several roles in lipid metabolism. [4]
  • APOC-l increases atherosclerosis by inducing hyperlipidemia, but decreases macrophage lipid accumulation in vitro, its production by macrophages locally in the arterial wall does not affect atherosclerosis development in vivo. [4]
  • APOC-I is a direct inhibitor of the lipoprotein lipase activity independent of the very-low-density lipoprotein receptor and apolipoprotein C-3. [5]

Classification

Hormone function

  • development and growth
    • apoptosis
    • metabolism
      • nutrient supply

      Chemical classification

      • hormone
        • genome-encoded
          • apoproteins

        Composition

        Sequence 
        TPDVSSALD KLKEFGNTL EDKARELIS 
RIKQSELSA KMREWFSET FQKVKEKLK 
IDS

        Links to other resources

        UniProt P02654
        Ensembl ENST00000252491
        KEGG hsa:341

        • Anatomical structure: hepatocyte

        • Anatomical structure: small_intestine

        • Anatomical structure: large_intestine

        Targets

        Cell
        No records found.
        Reference