Status
Please wait ...

Details for messenger / hormone: TNFSF10

EndoNet ID: ENH00551

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • TNF-related apoptosis-inducing ligand
  • TRAIL protein
  • apo-2 ligand
  • Apo-2L
  • TNFSF10
  • tumor necrosis factor ligand superfamily member 10

General information

  • Tumour cells are sensitive to TRAIL-mediated apoptosis and normal tissues resistant. [1]
  • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG.

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • apoptosis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • TNF family

        Composition

        Subunit (3 times)

        Sequence 
        MAMMEVQGG PSLGQTCVL IVIFTVLLQ 
SLCVAVTYV YFTNELKQM QDKYSKSGI 
ACFLKEDDS YWDPNDEES MNSPCWQVK 
WQLRQLVRK MILRTSEET ISTVQEKQQ 
NISPLVRER GPQRVAAHI TGTRGRSNT 
LSSPNSKNE KALGRKINS WESSRSGHS 
FLSNLHLRN GELVIHEKG FYYIYSQTY 
FRFQEEIKE NTKNDKQMV QYIYKYTSY 
PDPILLMKS ARNSCWSKD AEYGLYSIY 
QGGIFELKE NDRIFVSVT NEHLIDMDH 
EASFFGAFL VG

        Links to other resources

        UniProt P50591
        Ensembl ENST00000241261
        KEGG hsa:8743

        • Anatomical structure: spleen

        • Anatomical structure: lung

        • Anatomical structure: prostate

        Targets

        Reference