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Details for messenger / hormone: APOD

EndoNet ID: ENH00556

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Synonyms

  • APOD
  • Apo-D
  • apolipoprotein D

General information

  • ApoD is involved in regenerative processes and scar formation in the peri-infarct area presumably by enhancing lipid trafficking. [1]
  • Apolipoprotein D, a lipocalin transporter of small hydrophobic molecules, could play an important role in several neurodegenerative diseases. [2]
  • Apolipoprotein D is elevated in Alzheimer's disease cortex, localizing to cells, blood vessels, and neuropil deposits (plaques). Elevated apoD in AD brain may influence Abeta aggregation, or facilitate phagocytosis and transport of Abeta fibrils from plaques to cerebral vasculature. [3]
  • Apo D is a secreted lipocalin in the nervous system that may be related to processes of reinnervation and regeneration. Under normal conditions, Apo D is present in the central nervous system in oligodendrocytes, astrocytes, and some scattered neurons. [4]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • apoproteins

      Composition

      Sequence 
      AFHLGKCPN PPVQENFDV NKYLGRWYE 
IEKIPTTFE NGRCIQANY SLMENGKIK 
VLNQELRAD GTVNQIEGE ATPVNLTEP 
AKLEVKFSW FMPSAPYWI LATDYENYA 
LVYSCTCII QLFHVDFAW ILARNPNLP 
PETVDSLKN ILTSNNIDV KKMTVTDQV 
NCPKLS

      Links to other resources

      UniProt P05090
      Ensembl ENST00000343267
      KEGG hsa:347

      • Anatomical structure: astrocyte

      • Anatomical structure: oligodendrocyte

      • Anatomical structure: large_intestine

      • Anatomical structure: pancreas

      • Anatomical structure: kidney

      • Anatomical structure: placenta

      • Anatomical structure: spleen

      Targets

      Cell
      No records found.
      Reference