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Details for messenger / hormone: semaphorin 3B

EndoNet ID: ENH00559

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Synonyms

  • Semaphorin-V
  • semaphorin 3B
  • semaphorin-3B
  • semaphorin V
  • sema V
  • sema A(V)
  • SEMA3B
  • SEMA5
  • SEMAA
  • semaphorin A
  • semaphorin A(V)
  • SEMAV
  • LUCA-1
  • SemA

General information

  • Loss of the 3p21.3-encoded semaphorins, SEMA3B and SEMA3F, is implicated in lung cancer development. [1]
  • SEMA3B promoter region is frequently hypermethylated and downregulated in lung cancer. [2]
  • SEMA3B has been implicated as important for neuronal development and as a tumor suppressor in lung cancer. [3]
  • Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. [4]
  • Sema3B might play some role in regulating cell growth as a mediator of p53 tumor-suppressor activity. [5]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      Composition

      Semaphorin-3B, chain

      Sequence
      APSPPRLRL SFQELQAWH GLQTFSLER 
      TCCYQALLV DEERGRLFV GAENHVASL 
      NLDNISKRA KKLAWPAPV EWREECNWA 
      GKDIGTECM NFVKLLHAY NRTHLLACG 
      TGAFHPTCA FVEVGHRAE EPVLRLDPG 
      RIEDGKGKS PYDPRHRAA SVLVGEELY 
      SGVAADLMG RDFTIFRSL GQRPSLRTE 
      PHDSRWLNE PKFVKVFWI PESENPDDD 
      KIYFFFRET AVEAAPALG RLSVSRVGQ 
      ICRNDVGGQ RSLVNKWTT FLKARLVCS 
      VPGVEGDTH FDQLQDVFL LSSRDHRTP 
      LLYAVFSTS SSIFQGSAV CVYSMNDVR 
      RAFLGPFAH KEGPMHQWV SYQGRVPYP 
      RPGMCPSKT FGTFSSTKD FPDDVIQFA 
      RNHPLMYNS VLPTGGRPL FLQVGANYT 
      FTQIAADRV AAADGHYDV LFIGTDVGT 
      VLKVISVPK GSRPSAEGL LLEELHVFE 
      DSAAVTSMQ ISSKRHQLY VASRSAVAQ 
      IALHRCAAH GRVCTECCL ARDPYCAWD 
      GVACTRFQP SAKRRFRRQ DVRNGDPST 
      LCSGDSSRP ALLEHKVFG VEGSSAFLE 
      CEPRSLQAR VEWTFQRAG VTAHTQVLA 
      EERTERTAR GLLLRRLRR RDSGVYLCA 
      AVEQGFTQP LRRLSLHVL SATQAERLA 
      RAEEAAPAA PPGPKLWYR DFLQLVEPG 
      GGGSANSLR MCRPQPALQ SLPLESRRK 
      GRNRRTHAP EPRAERGPR SATHW
      UniProt Q13214

      Semaphorin 3B isoform 1, mature peptide.

      Sequence
      APSPPRLRL SFQELQAWH GLQTFSLER 
      TCCYQALLV DEERGRLFV GAENHVASL 
      NLDNISKRA KKLAWPAPV EWREECNWA 
      GKDIGTECM NFVKLLHAY NRTHLLACG 
      TGAFHPTCA FVEVGHRAE EPVLRLDPG 
      RIEDGKGKS PYDPRHRAA SVLVGEELY 
      SGVAADLMG RDFTIFRSL GQRPSLRTE 
      PHDSRWLNE PKFVKVFWI PESENPDDD 
      KIYFFFRET AVEAAPALG RLSVSRVGQ 
      ICRNDVGGQ RSLVNKWTT FLKARLVCS 
      VPGVEGDTH FDQLQDVFL LSSRDHRTP 
      LLYAVFSTS SSIFQGSAV CVYSMNDVR 
      RAFLGPFAH KEGPMHQWV SYQGRVPYP 
      RPGMCPSKT FGTFSSTKD FPDDVIQFA 
      RNHPLMYNS VLPTGGRPL FLQVGANYT 
      FTQIAADRV AAADGHYDV LFIGTDVGT 
      VLKVISVPK GSRPSAEGL LLEELHVFE 
      DSAAVTSMQ ISSKRHQLY VASRSAVAQ 
      IALHRCAAH GRVCTECCL ARDPYCAWD 
      GVACTRFQP SAKRRFRRQ DVRNGDPST 
      LCSGDSSRP ALLEHKVFG VEGSSAFLE 
      CEPRSLQAR VEWTFQRAG VTAHTQVLA 
      EERTERTAR GLLLRRLRR RDSGVYLCA 
      AVEQGFTQP LRRLSLHVL SATQAERLA 
      RAEEAAPAA PPGPKLWYR DFLQLVEPG 
      GGGSANSLR MCRPQPALQ SLPLESRRK 
      GRNRRTHAP EPRAERGPR SATHW

      Semaphorin 3B isoform 2, mature peptide.

      Sequence
      APSPPRLRL SFQELQAWH GLQTFSLER 
      TCCYQALLV DEERGRLFV GAENHVASL 
      NLDNISKRA KKLAWPAPV EWREECNWA 
      GKDIGTECM NFVKLLHAY NRTHLLACG 
      TGAFHPTCA FVEVGHRAE EPVLRLDPG 
      RIEDGKGKS PYDPRHRAA SVLVGEELY 
      SGVAADLMG RDFTIFRSL GQRPSLRTE 
      PHDSRWLNE PKFVKVFWI PESENPDDD 
      KIYFFFRET AVEAAPALG RLSVSRVGQ 
      ICRNDVGGQ RSLVNKWTT FLKARLVCS 
      VPGVEGDTH FDQLQDVFL LSSRDHRTP 
      LLYAVFSTS SIFQGSAVC VYSMNDVRR 
      AFLGPFAHK EGPMHQWVS YQGRVPYPR 
      PGMCPSKTF GTFSSTKDF PDDVIQFAR 
      NHPLMYNSV LPTGGRPLF LQVGANYTF 
      TQIAADRVA AADGHYDVL FIGTDVGTV 
      LKVISVPKG SRPSAEGLL LEELHVFED 
      SAAVTSMQI SSKRHQLYV ASRSAVAQI 
      ALHRCAAHG RVCTECCLA RDPYCAWDG 
      VACTRFQPS AKRRFRRQD VRNGDPSTL 
      CSGDSSRPA LLEHKVFGV EGSSAFLEC 
      EPRSLQARV EWTFQRAGV TAHTQVLAE 
      ERTERTARG LLLRRLRRR DSGVYLCAA 
      VEQGFTQPL RRLSLHVLS ATQAERLAR 
      AEEAAPAAP PGPKLWYRD FLQLVEPGG 
      GGSANSLRM CRPQPALQS LPLESRRKG 
      RNRRTHAPE PRAERGPRS ATHW

      Links to other resources

      UniProt Q13214
      Ensembl ENST00000414456
      KEGG hsa:7869
      • Anatomical structure: brain

      • Anatomical structure: muscle

      Targets

      Cellneuropilin 1neuropilin-2
      blood vessel Present
      Phenotypes
      • excess of capillary formation
      • patterning of blood vessels
      bone marrow Present
      brain Present
      Phenotypes
      • axon guidance
      glomerulus Present
      Phenotypes
      • induction of podocyte apoptosis
      • formation of glomerular filter barrier
      • inhibition of glomerular capillary lumen development
      • patterning of blood vessels
      • positive regulation of apoptosis
      heart Present
      Phenotypes
      • patterning of blood vessels
      kidney Present
      Phenotypes
      • inhibition of ureteric bud branching
      • excess of endothelial cells
      • podocyte differentiation
      • cell differentiation
      • acute nephrotic range proteinuria
      lung Present
      mammary gland Present
      neuron Present
      Phenotypes
      • axon guidance
      pancreas Present
      placenta Present
      podocyte Present
      Present
      skeleton muscle Present
      vascularendothelial cell Present
      Phenotypes
      • regulation of angiogenesis
      Reference