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Details for messenger / hormone: semaphorin 3F

EndoNet ID: ENH00560

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Synonyms

  • semaphorin 3F
  • SEMA3F
  • semaphorin-3F
  • semaphorin IV
  • sema IV
  • sema III/F
  • lambda 5 semaphorin
  • semaphorin III/F
  • SEMAK
  • SEMA4
  • SEMA-IV

General information

  • In this in vivo lung cancer model, SEMA3F has potent antitumor effects, which may impinge on activated integrin and MAPK signaling. [1]
  • Loss of the 3p21.3-encoded semaphorins, SEMA3B and SEMA3F, is implicated in lung cancer development. [1]
  • Neuropilin-2 (np-2) is a receptor for semaphorin-3F (sema-3F) and semaphorin-3C (sema-3C). [2]
  • Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling. [3]
  • Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. [4]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    Semaphorin-3F, chain

    Sequence 
    SFPTQDHLP ATPRVRLSF KELKATGTA 
HFFNFLLNT TDYRILLKD EDHDRMYVG 
SKDYVLSLD LHDINREPL IIHWAASPQ 
RIEECVLSG KDVNGECGN FVRLIQPWN 
RTHLYVCGT GAYNPMCTY VNRGRRAQA 
TPWTQTQAV RGRGSRATD GALRPMPTA 
PRQDYIFYL EPERLESGK GKCPYDPKL 
DTASALINE ELYAGVYID FMGTDAAIF 
RTLGKQTAM RTDQYNSRW LNDPSFIHA 
ELIPDSAER NDDKLYFFF RERSAEAPQ 
SPAVYARIG RICLNDDGG HCCLVNKWS 
TFLKARLVC SVPGEDGIE THFDELQDV 
FVQQTQDVR NPVIYAVFT SSGSVFRGS 
AVCVYSMAD IRMVFNGPF AHKEGPNYQ 
WMPFSGKMP YPRPGTCPG GTFTPSMKS 
TKDYPDEVI NFMRSHPLM YQAVYPLQR 
RPLVVRTGA PYRLTTIAV DQVDAADGR 
YEVLFLGTD RGTVQKVIV LPKDDQELE 
ELMLEEVEV FKDPAPVKT MTISSKRQQ 
LYVASAVGV THLSLHRCQ AYGAACADC 
CLARDPYCA WDGQACSRY TASSKRRSR 
RQDVRHGNP IRQCRGFNS NANKNAVES 
VQYGVAGSA AFLECQPRS PQATVKWLF 
QRDPGDRRR EIRAEDRFL RTEQGLLLR 
ALQLSDRGL YSCTATENN FKHVVTRVQ 
LHVLGRDAV HAALFPPLS MSAPPPPGA 
GPPTPPYQE LAQLLAQPE VGLIHQYCQ 
GYWRHVPPS PREAPGAPR SPEPQDQKK 
PRNRRHHPP DT
    UniProt Q13275

    Links to other resources

    UniProt Q13275
    Ensembl ENST00000002829
    KEGG hsa:6405

    • Anatomical structure: brain

    • Anatomical structure: placenta

    • Anatomical structure: mammary_gland

    • Anatomical structure: kidney

    • Anatomical structure: lung

    • Anatomical structure: heart

    • Anatomical structure: neuron

    • Anatomical structure: podocyte

      • Semaphorins 3A (sema 3A) and 3F are expressed by podocytes in vivo throughout ontogeny. [5]

    Targets

    Cellneuropilin-2PLXNA1
    neuron Present
    Phenotypes
    • axon guidance
    podocyte Present
    vascularendothelial cell Present
    Phenotypes
    • regulation of angiogenesis
    Reference