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Details for messenger / hormone: semaphorin 3C

EndoNet ID: ENH00561

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Synonyms

  • Semaphorin-E
  • semaphorin 3C
  • semaphorin-3C
  • semaphorin E
  • sema E
  • SEMA3C
  • SEMAE
  • SemE

General information

  • Neuropilin-2 (np-2) is a receptor for semaphorin-3F (sema-3F) and semaphorin-3C (sema-3C). [1]
  • The GATA-6 transcription factor regulates semaphorin 3C. [2]
  • Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture. [3]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    Semaphorin-3C, chain

    Sequence
    GSSQPQARV YLTFDELRE TKTSEYFSL 
    SHHPLDYRI LLMDEDQDR IYVGSKDHI 
    LSLNINNIS QEALSVFWP ASTIKVEEC 
    KMAGKDPTH GCGNFVRVI QTFNRTHLY 
    VCGSGAFSP VCTYLNRGR RSEDQVFMI 
    DSKCESGKG RCSFNPNVN TVSVMINEE 
    LFSGMYIDF MGTDAAIFR SLTKRNAVR 
    TDQHNSKWL SEPMFVDAH VIPDGTDPN 
    DAKVYFFFK EKLTDNNRS TKQIHSMIA 
    RICPNDTGG LRSLVNKWT TFLKARLVC 
    SVTDEDGPE THFDELEDV FLLETDNPR 
    TTLVYGIFT TSSSVFKGS AVCVYHLSD 
    IQTVFNGPF AHKEGPNHQ LISYQGRIP 
    YPRPGTCPG GAFTPNMRT TKEFPDDVV 
    TFIRNHPLM YNSIYPIHK RPLIVRIGT 
    DYKYTKIAV DRVNAADGR YHVLFLGTD 
    RGTVQKVVV LPTNNSVSG ELILEELEV 
    FKNHAPITT MKISSKKQQ LYVSSNEGV 
    SQVSLHRCH IYGTACADC CLARDPYCA 
    WDGHSCSRF YPTGKRRSR RQDVRHGNP 
    LTQCRGFNL KAYRNAAEI VQYGVKNNT 
    TFLECAPKS PQASIKWLL QKDKDRRKE 
    VKLNERIIA TSQGLLIRS VQGSDQGLY 
    HCIATENSF KQTIAKINF KVLDSEMVA 
    VVTDKWSPW TWASSVRAL PFHPKDIMG 
    AFSHSEMQM INQYCKDTR QQHQQGDES 
    QKMRGDYGK LKALINSRK SRNRRNQLP 
    ES
    UniProt Q99985

    Links to other resources

    UniProt Q99985
    Ensembl ENST00000419255
    KEGG hsa:10512
    • Anatomical structure: testis

    • Anatomical structure: heart

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: colon

    • Anatomical structure: small_intestine

    • Anatomical structure: ovary

    • Anatomical structure: prostate

    Targets

    Cellneuropilin-2PLXNA1
    neuron Present
    Phenotypes
    • axon guidance
    podocyte Present
    vascularendothelial cell Present
    Phenotypes
    • regulation of angiogenesis
    Reference