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Details for messenger / hormone: semaphorin 3D

EndoNet ID: ENH00563

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Synonyms

  • semaphorin 3D
  • semaphorin-3D
  • SEMA3D
  • UNQ760/PRO1491
  • COLL-2
  • SEMA-Z2
  • MGC39708
  • collapsin 2

General information

  • Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish. [1]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    Semaphorin-3D, chain

    Sequence
    TLKQNIPRL KLTYKDLLL SNSCIPFLG 
    SSEGLDFQT LLLDEERGR LLLGAKDHI 
    FLLSLVDLN KNFKKIYWP AAKERVELC 
    KLAGKDANT ECANFIRVL QPYNKTHIY 
    VCGTGAFHP ICGYIDLGV YKEDIIFKL 
    DTHNLESGR LKCPFDPQQ PFASVMTDE 
    YLYSGTASD FLGKDTAFT RSLGPTHDH 
    HYIRTDISE HYWLNGAKF IGTFFIPDT 
    YNPDDDKIY FFFRESSQE GSTSDKTIL 
    SRVGRVCKN DVGGQRSLI NKWTTFLKA 
    RLICSIPGS DGADTYFDE LQDIYLLPT 
    RDERNPVVY GVFTTTSSI FKGSAVCVY 
    SMADIRAVF NGPYAHKES ADHRWVQYD 
    GRIPYPRPG TCPSKTYDP LIKSTRDFP 
    DDVISFIKR HSVMYKSVY PVAGGPTFK 
    RINVDYRLT QIVVDHVIA EDGQYDVMF 
    LGTDIGTVL KVVSISKEK WNMEEVVLE 
    ELQIFKHSS IILNMELSL KQQQLYIGS 
    RDGLVQLSL HRCDTYGKA CADCCLARD 
    PYCAWDGNA CSRYAPTSK RRARRQDVK 
    YGDPITQCW DIEDSISHE TADEKVIFG 
    IEFNSTFLE CIPKSQQAT IKWYIQRSG 
    DEHREELKP DERIIKTEY GLLIRSLQK 
    KDSGMYYCK AQEHTFIHT IVKLTLNVI 
    ENEQMENTQ RAEHEEGKV KDLLAESRL 
    RYKDYIQIL SSPNFSLDQ YCEQMWHRE 
    KRRQRNKGG PKWKHMQEM KKKRNRRHH 
    RDLDELPRA VAT
    UniProt O95025

    Links to other resources

    UniProt O95025
    Ensembl ENST00000284136
    KEGG hsa:223117
    • Anatomical structure: testis

    Targets

    Cellneuropilin 1
    blood vessel Present
    Phenotypes
    • excess of capillary formation
    • patterning of blood vessels
    bone marrow Present
    brain Present
    Phenotypes
    • axon guidance
    glomerulus Present
    Phenotypes
    • induction of podocyte apoptosis
    • formation of glomerular filter barrier
    • inhibition of glomerular capillary lumen development
    • patterning of blood vessels
    • positive regulation of apoptosis
    heart Present
    Phenotypes
    • patterning of blood vessels
    kidney Present
    Phenotypes
    • inhibition of ureteric bud branching
    • excess of endothelial cells
    • podocyte differentiation
    • cell differentiation
    • acute nephrotic range proteinuria
    lung Present
    mammary gland Present
    pancreas Present
    placenta Present
    podocyte Present
    skeleton muscle Present
    Reference