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Details for messenger / hormone: semaphorin 3E

EndoNet ID: ENH00564

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Synonyms

  • semaphorin 3E
  • semaphorin-3E
  • SEMA3E
  • KIAA0331
  • SEMAH
  • COLL-5
  • semaphorin H

General information

  • Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. [1]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    Composition

    Semaphorin-3E, chain

    Sequence
    ADTTHPRLR LSHKELLNL NRTSIFHSP 
    FGFLDLHTM LLDEYQERL FVGGRDLVY 
    SLSLERISD GYKEIHWPS TALKMEECI 
    MKGKDAGEC ANYVRVLHH YNRTHLLTC 
    GTGAFDPVC AFIRVGYHL EDPLFHLES 
    PRSERGRGR CPFDPSSSF ISTLIGSEL 
    FAGLYSDYW SRDAAIFRS MGRLAHIRT 
    EHDDERLLK EPKFVGSYM IPDNEDRDD 
    NKVYFFFTE KALEAENNA HAIYTRVGR 
    LCVNDVGGQ RILVNKWST FLKARLVCS 
    VPGMNGIDT YFDELEDVF LLPTRDHKN 
    PVIFGLFNT TSNIFRGHA ICVYHMSSI 
    RAAFNGPYA HKEGPEYHW SVYEGKVPY 
    PRPGSCASK VNGGRYGTT KDYPDDAIR 
    FARSHPLMY QAIKPAHKK PILVKTDGK 
    YNLKQIAVD RVEAEDGQY DVLFIGTDN 
    GIVLKVITI YNQEMESME EVILEELQI 
    FKDPVPIIS MEISSKRQQ LYIGSASAV 
    AQVRFHHCD MYGSACADC CLARDPYCA 
    WDGISCSRY YPTGTHAKR RFRRQDVRH 
    GNAAQQCFG QQFVGDALD KTEEHLAYG 
    IENNSTLLE CTPRSLQAK VIWFVQKGR 
    ETRKEEVKT DDRVVKMDL GLLFLRLHK 
    SDAGTYFCQ TVEHSFVHT VRKITLEVV 
    EEEKVEDMF NKDDEEDRH HRMPCPAQS 
    SISQGAKPW YKEFLQLIG YSNFQRVEE 
    YCEKVWCTD RKRKKLKMS PSKWKYANP 
    QEKKLRSKP EHYRLPRHT LDS
    UniProt O15041

    Links to other resources

    UniProt O15041
    Ensembl ENST00000307792
    KEGG hsa:9723
    • Anatomical structure: brain

    Targets

    CellPLXND1
    aorta Present
    brain Present
    Phenotypes
    • CHARGE syndrome
    colon Present
    continuous vascular endothelial cell of blood vessels and lymphatics Present
    endocardium Present
    heart Present
    intersomitic vessel Present
    kidney Present
    lung Present
    peripheral blood leukocytes Present
    placenta Present
    pulmonary vessels Present
    skeleton muscle Present
    small intestine Present
    spleen Present
    testis Present
    thymus Present
    vascularendothelial cell Present
    Reference