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Details for messenger / hormone: SAA1

EndoNet ID: ENH00565

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Synonyms

  • SAA1
  • serum amyloid A1
  • PIG4
  • MGC111216
  • tumor protein p53 inducible protein 4
  • p53 inducible protein 4

General information

  • SAA1 is the predominant isoform of acute phase human SAA deposited as AA amyloid fibrils in reactive systemic amyloidosis. [1]
  • The human acute-phase protein serum amyloid A (A-SAA), encoded by the SAA1 and SAA2 genes, is dramatically induced by pro-inflammatory mediators during the acute-phase response to infection or injury. [2]
  • Serum amyloid A, a plasma precursor of reactive amyloid deposits, is a multigene product. SAA1 and SAA2, with primary structures that are 93% identical (98 of 104 amino acids), behave as acute phase proteins. [3]

Classification

Hormone function

  • immune response
    • activation
    • metabolism
      • cell metabolism

      Chemical classification

      • hormone
        • genome-encoded
          • cystatin family

        Composition

        serum amyloid A1 mature peptide

        Sequence 
        RSFFSFLGE AFDGARDMW RAYSDMREA 
NYIGSDKYF HARGNYDAA KRGPGGVWA 
AEAISDARE NIQRFFGHG AEDSLADQA 
ANEWGRSGK DPNHFRPAG LPEKY

        Links to other resources

        • Anatomical structure: liver

          • SAA1 (Serum amyloid A1) protein is produced mainly in the liver and circulates in low levels in the blood.

          Influenced by:

          • IL-6R
            in hepatocyte

        Targets

        Cell
        No records found.
        Reference