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Details for messenger / hormone: APRIL

EndoNet ID: ENH00566

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Synonyms

  • APRIL
  • tumor necrosis factor ligand superfamily member 13
  • a proliferation-inducing ligand
  • TNF- and APOL-related leukocyte expressed ligand 2
  • TALL-2
  • TNF-related death ligand 1
  • TRDL-1
  • CD256 antigen
  • TNFSF13
  • tumor necrosis factor ligand 13

General information

  • The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. [1]
  • Function: promotes IgA class switching during immune response. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    TNF ligand superfamily member 13 isoform beta

    Sequence 
    AVLTQKQKN DSDVTEVMW QPALRRGRG 
LQAQGYGVR IQDAGVYLL YSQVLFQDV 
TFTMGQVVS REGQGRQET LFRCIRSMP 
SHPDRAYNS CYSAGVFHL HQGDILSVI 
IPRARAKLN LSPHGTFLG FVKL

    TNF ligand superfamily member 13 isoform alpha

    Sequence 
    AVLTQKQKK QHSVLHLVP INATSKDDS 
DVTEVMWQP ALRRGRGLQ AQGYGVRIQ 
DAGVYLLYS QVLFQDVTF TMGQVVSRE 
GQGRQETLF RCIRSMPSH PDRAYNSCY 
SAGVFHLHQ GDILSVIIP RARAKLNLS 
PHGTFLGFV KL

    TNF ligand superfamily member 13 isoform gamma

    Sequence 
    AVLTQKQKK QHSVLHLVP INATSKDDS 
DVTEVMWQP ALRRGRGLQ AQGYGVRIQ 
DAGVYLLYS QVLFQDVTF TMGQVVSRE 
GQGRQETLF RCIRSMPSH PDRAYNSCY 
SAGVFHLHQ GDILSVIIP RARAKLNLS 
PHGTFLGL

    Links to other resources

    UniProt O75888
    Ensembl ENST00000338784
    KEGG hsa:8741

    • Anatomical structure: macrophage

    • Anatomical structure: monocyte

    Targets

    CellTACITNFRSF17
    B-lymphocyte Present
    Phenotypes
    • negative regulation of lymphocyte apoptosis
    small intestine Present
    spleen Present
    thymus Present
    Reference