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Details for messenger / hormone: BAFF

EndoNet ID: ENH00568

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Synonyms

  • B-cell-activating factor
  • BAFF
  • TNFSF13B
  • TNFSF20
  • ZTNF4
  • BLYS
  • TALL-1
  • TALL1
  • THANK
  • tumor necrosis factor ligand superfamily member 13B
  • TNF- and APOL-related leukocyte expressed ligand 1
  • B lymphocyte stimulator
  • B cell-activating factor
  • dendritic cell-derived TNF-like molecule

General information

  • BAFF is a member of the TNF superfamily of ligands. [1]
  • BAFF is a survival factor for the peripheral B cells and may play a role in B cell-mediated diseases. [1]
  • BAFF plays an important role in the pathogenesis of Idiopathic thrombocytopenic purpura and offers the opportunity to improve our therapeutic approach. [2]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TNF family

      Composition

      TNF ligand superfamily member 13b, soluble form.

      Sequence 
      AVQGPEETV TQDCLQLIA DSETPTIQK 
GSYTFVPWL LSFKRGSAL EEKENKILV 
KETGYFFIY GQVLYTDKT YAMGHLIQR 
KKVHVFGDE LSLVTLFRC IQNMPETLP 
NNSCYSAGI AKLEEGDEL QLAIPRENA 
QISLDGDVT FFGALKLL
      UniProt Q9Y275

      Links to other resources

      UniProt Q9Y275
      Ensembl ENST00000375887
      KEGG hsa:10673

      • Anatomical structure: monocyte

      • Anatomical structure: macrophage

      • Anatomical structure: spleen

      • Anatomical structure: lymph_node

      • Anatomical structure: bone_marrow

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

      • Anatomical structure: placenta

      • Anatomical structure: heart

      • Anatomical structure: lung

      • Anatomical structure: thymus

      • Anatomical structure: pancreas

      • Anatomical structure: T-lymphocyte

      Targets

      CellTACITNFRSF13CTNFRSF17
      B-lymphocyte Present
      Phenotypes
      • negative regulation of B cell apoptosis
      		Present
      Phenotypes
      • negative regulation of lymphocyte apoptosis
      lymph node Present
      Phenotypes
      • negative regulation of lymphocyte apoptosis
      small intestine Present
      spleen Present
      		Present
      Phenotypes
      • negative regulation of lymphocyte apoptosis
      thymus Present
      		Present
      Phenotypes
      • negative regulation of lymphocyte apoptosis
      Reference