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Details for messenger / hormone: WISP1

EndoNet ID: ENH00573

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Synonyms

  • WISP1
  • CCN family member 4
  • WNT1-inducible-signaling pathway protein 1
  • WISP-1
  • WNT1-inducible signaling pathway protein 1
  • wnt-1-induced secreted protein
  • CCN4

General information

  • WISP-1 acts as a tumor suppressor and plays an important role in breast cancer. [1]
  • WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. [2]
  • WISP-1 is a cysteine-rich, secreted factor belonging to the CCN family. [3]
  • WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. [4]
  • WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast proliferation, and ECM expression in vitro. [5]
  • WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. [6]
  • WISP-1 is a member of the CCN family of growth factors. [6]
  • Overexpression of WISP-1 down-regulates motility and invasion of lung cancer cells through inhibition of Rac activation. [3]
  • WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. [7]
  • WISP-1 binds to decorin and biglycan. [8]
  • WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma. [9]
  • WISP-1 plays a critical role in post-myocardial infarction remodeling. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • apoptosis
        • embryogenesis

        Chemical classification

        • hormone
          • genome-encoded
            • CCN family

          Composition

          WISP-1 isoform 1, chain

          Sequence 
          TALSPAPTT MDFTPAPLE DTSSRPQFC 
KWPCECPPS PPRCPLGVS LITDGCECC 
KMCAQQLGD NCTEAAICD PHRGLYCDY 
SGDRPRYAI GVCAQVVGV GCVLDGVRY 
NNGQSFQPN CKYNCTCID GAVGCTPLC 
LRVRPPRLW CPHPRRVSI PGHCCEQWV 
CEDDAKRPR KTAPRDTGA FDAVGEVEA 
WHRNCIAYT SPWSPCSTS CGLGVSTRI 
SNVNAQCWP EQESRLCNL RPCDVDIHT 
LIKAGKKCL AVYQPEASM NFTLAGCIS 
TRSYQPKYC GVCMDNRCC IPYKSKTID 
VSFQCPDGL GFSRQVLWI NACFCNLSC 
RNPNDIFAD LESYPDFSE IAN
          UniProt O95388-1

          WISP-1 isoform 2; WISP1v.

          Sequence 
          MRWFLPWTL AAVTAAAAS TVLATALSP 
APTTMDFTP APLEDTSSR PQFCKWPCE 
CPPSPPRCP LGVSLITDG CECCKMCAQ 
QLGDNCTEA AICDPHRGL YCDYSGDRP 
RYAIGVCAH AVGEVEAWH RNCIAYTSP 
WSPCSTSCG LGVSTRISN VNAQCWPEQ 
ESRLCNLRP CDVDIHTLI KAGKKCLAV 
YQPEASMNF TLAGCISTR SYQPKYCGV 
CMDNRCCIP YKSKTIDVS FQCPDGLGF 
SRQVLWINA CFCNLSCRN PNDIFADLE 
SYPDFSEIA N
          UniProt O95388-2

          Links to other resources

          UniProt O95388
          Ensembl ENST00000250160
          KEGG hsa:8840

          • Anatomical structure: heart

          • Anatomical structure: kidney

          • Anatomical structure: lung

          • Anatomical structure: pancreas

          • Anatomical structure: placenta

          • Anatomical structure: ovary

          • Anatomical structure: small_intestine

          • Anatomical structure: spleen

          Targets

          Cell
          No records found.
          Reference