Status
Please wait ...

Details for messenger / hormone: WISP3

EndoNet ID: ENH00574

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • CCN family member 6
  • WNT1-inducible-signaling pathway protein 3
  • WNT1-inducible signaling pathway protein 3
  • WISP3
  • WISP-3
  • CCN6
  • PPAC
  • LIBC
  • lost in inflammatory breast cancer
  • wnt-induced secreted protein-3

General information

  • WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. [1]
  • Essential for normal post-natal skeletal growth and cartilage homeostasis. [2]
  • WISP-3 functions as a ligand and promotes superoxide dismutase activity. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • CCN family

      Composition

      WISP-3 chain

      Sequence 
      TGPLDTTPE GRPGEVSDA PQRKQFCHW 
PCKCPQQKP RCPPGVSLV RDGCGCCKI 
CAKQPGEIC NEADLCDPH KGLYCDYSV 
DRPRYETGV CAYLVAVGC EFNQVHYHN 
GQVFQPNPL FSCLCVSGA IGCTPLFIP 
KLAGSHCSG AKGGKKSDQ SNCSLEPLL 
QQLSTSYKT MPAYRNLPL IWKKKCLVQ 
ATKWTPCSR TCGMGISNR VTNENSNCE 
MRKEKRLCY IQPCDSNIL KTIKIPKGK 
TCQPTFQLS KAEKFVFSG CSSTQSYKP 
TFCGICLDK RCCIPNKSK MITIQFDCP 
NEGSFKWKM LWITSCVCQ RNCREPGDI 
FSELKIL
      UniProt O95389

      Links to other resources

      UniProt O95389
      Ensembl ENST00000368666
      KEGG hsa:8838

      • Anatomical structure: kidney

      • Anatomical structure: testis

      • Anatomical structure: placenta

      • Anatomical structure: ovary

      • Anatomical structure: small_intestine

      • Anatomical structure: articular_cartilage

      • Anatomical structure: chondrocyte

      • Anatomical structure: synovial_cell_phagocytic

      • Anatomical structure: prostate

      Targets

      Cell
      No records found.
      Reference