Please wait ...

Details for messenger / hormone: defensin alpha 1

EndoNet ID: ENH00577

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • defensin alpha 1
  • DEFA1
  • DEF1
  • HNP-1
  • HP-1
  • MGC138393
  • DEFA2
  • neutrophil defensin 1
  • HP1
  • alpha defensin-1
  • NP-1
  • NP1
  • neutrophil peptide 1

General information

  • Antimicrobial peptide, chemotactic for T cells.
  • Defensins are cysteine-rich cationic antimicrobial peptides that play an important role in innate immunity and are known to contribute to the regulation of host adaptive immunity. [1]
  • In addition to direct antimicrobial activities, it has been recently reported that alpha-defensins, mainly present in neutrophils in the lung, have a cytotoxic effect and induce IL-8 production from airway epithelial cells. [1]
  • Alpha-defensin 1 (human neutrophil protein 1) is an antichemotactic agent for human polymorphonuclear leukocytes. [2]


Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • antimicrobial peptides
          • alpha-defensin family


      Neutrophil defensin 1.

      UniProt P59665

      Links to other resources

      UniProt P59665alp
      • Anatomical structure: neutrophil_granulocyte

      • Anatomical structure: leukocyte

      • Anatomical structure: bone_marrow

      • Anatomical structure: spleen

      • Anatomical structure: thymus


      No records found.