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Details for messenger / hormone: defensin alpha 1

EndoNet ID: ENH00577

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Synonyms

  • defensin alpha 1
  • DEFA1
  • DEF1
  • HNP-1
  • HP-1
  • MGC138393
  • DEFA2
  • neutrophil defensin 1
  • HP1
  • alpha defensin-1
  • NP-1
  • NP1
  • neutrophil peptide 1

General information

  • Antimicrobial peptide, chemotactic for T cells.
  • Defensins are cysteine-rich cationic antimicrobial peptides that play an important role in innate immunity and are known to contribute to the regulation of host adaptive immunity. [1]
  • In addition to direct antimicrobial activities, it has been recently reported that alpha-defensins, mainly present in neutrophils in the lung, have a cytotoxic effect and induce IL-8 production from airway epithelial cells. [1]
  • Alpha-defensin 1 (human neutrophil protein 1) is an antichemotactic agent for human polymorphonuclear leukocytes. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • antimicrobial peptides
          • alpha-defensin family

      Composition

      Neutrophil defensin 1.

      Sequence 
      ACYCRIPAC IAGERRYGT CIYQGRLWA 
FCC
      UniProt P59665

      Links to other resources

      UniProt P59665alp

      • Anatomical structure: neutrophil_granulocyte

      • Anatomical structure: leukocyte

      • Anatomical structure: bone_marrow

      • Anatomical structure: spleen

      • Anatomical structure: thymus

      Targets

      Cell
      No records found.
      Reference