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Details for messenger / hormone: GDF-8

EndoNet ID: ENH00579

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Synonyms

  • GDF-8
  • myostatin
  • growth differentiation factor 8
  • GDF8
  • growth/differentiation factor 8
  • MSTN
  • GDF 8

General information

  • Myostatin is a negative regulator of skeletal muscle growth. [1]
  • Myostatin knockout in mice increases myogenesis and decreases adipogenesis. [2]
  • Myostatin is a member of the transforming growth factor-beta family of regulatory factors, also known as growth and differentiation factor 8. [3]

Classification

Hormone function

  • development and growth
    • growth inhibition

    Chemical classification

    Composition

    Growth differentiation factor 8, chain.

    Sequence 
    DFGLDCDEH STESRCCRY PLTVDFEAF 
GWDWIIAPK RYKANYCSG ECEFVFLQK 
YPHTHLVHQ ANPRGSAGP CCTPTKMSP 
INMLYFNGK EQIIYGKIP AMVVDRCGC 
S
    UniProt O14793

    Links to other resources

    UniProt O14793
    Ensembl ENST00000260950
    KEGG hsa:2660

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: colon

    • Anatomical structure: muscle

      • GDF-8 is expressed in many different muscles throughout the body. [4]

    Targets

    Cellactivin receptor type 2B
    cell of endometrium of uterus Present
    Phenotypes
    • cell differentiation
    pancreatic islets Present
    Phenotypes
    • embryonic digestive tract development
    Reference