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Details for messenger / hormone: SEMA4D

EndoNet ID: ENH00580

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Synonyms

  • SEMA4D
  • semaphorin-4D
  • semaphorin 4D
  • leukocyte activation antigen CD100
  • BB18
  • A8
  • GR3
  • CD100

General information

  • CD100/Sema4D is a transmembrane protein containing an amino-terminal signal sequence followed by a sema domain, an immunoglobulin (Ig)-like domain, a lysinerich stretch, a hydrophobic transmembrane region and a cytoplasmic tail. [1]
  • CD100/Sema4D messenger RNA (mRN)A is expressed in a broad range of human tissues, including the embryonic and adult brain, kidney and heart. [2]
  • Several findings also suggest a role of CD100/Sema4D as a cell surface receptor. [3]
  • Human CD100/Sema4D functions possibly as a receptor for human plexin-B1. Although the physiological significance of CD100/Sema4D as a receptor remains to be determined, it is plausible that CD100/Sema4D possesses bidirectional functions in cognate cell-cell contacts. [4]
  • CD100/Sema4D may function as a receptor transmitting signals to lymphocytes. [5]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    Composition

    CD100/Sema4D (1 times)

    Sequence
    MRMCTPIRG LLMALAVMF GTAMAFAPI 
    PRITWEHRE VHLVQFHEP DIYNYSALL 
    LSEDKDTLY IGAREAVFA VNALNISEK 
    QHEVYWKVS EDKKAKCAE KGKSKQTEC 
    LNYIRVLQP LSATSLYVC GTNAFQPAC 
    DHLNLTSFK FLGKNEDGK GRCPFDPAH 
    SYTSVMVDG ELYSGTSYN FLGSEPIIS 
    RNSSHSPLR TEYAIPWLN EPSFVFADV 
    IRKSPDSPD GEDDRVYFF FTEVSVEYE 
    FVFRVLIPR IARVCKGDQ GGLRTLQKK 
    WTSFLKARL ICSRPDSGL VFNVLRDVF 
    VLRSPGLKV PVFYALFTP QLNNVGLSA 
    VCAYNLSTA EEVFSHGKY MQSTTVEQS 
    HTKWVRYNG PVPKPRPGA CIDSEARAA 
    NYTSSLNLP DKTLQFVKD HPLMDDSVT 
    PIDNRPRLI KKDVNYTQI VVDRTQALD 
    GTVYDVMFV STDRGALHK AISLEHAVH 
    IIEETQLFQ DFEPVQTLL LSSKKGNRF 
    VYAGSNSGV VQAPLAFCG KHGTCEDCV 
    LARDPYCAW SPPTATCVA LHQTESPSR 
    GLIQEMSGD ASVCPDKSK GSYRQHFFK 
    HGGTAELKC SQKSNLARV FWKFQNGVL 
    KAESPKYGL MGRKNLLIF NLSEGDSGV 
    YQCLSEERV KNKTVFQVV AKHVLEVKV 
    VPKPVVAPT LSVVQTEGS RIATKVLVA 
    STQGSSPPT PAVQATSSG AITLPPKPA 
    PTGTSCEPK IVINTVPQL HSEKTMYLK 
    SSDNRLLMS LFLFFFVLF LCLFFYNCY 
    KGYLPRQCL KFRSALLIG KKKPKSDFC 
    DREQSLKET LVEPGSFSQ QNGEHPKPA 
    LDTGYETEQ DTITSKVPT DREDSQRID 
    DLSARDKPF DVKCELKFA DSDADGD
    UniProt Q92854-1
    KEGG hsa:10507

    Links to other resources

    UniProt Q92854
    Ensembl ENST00000450295
    KEGG hsa:10507
    • Anatomical structure: skeleton_muscle

    • Anatomical structure: peripheral blood lymphocytes

    • Anatomical structure: spleen

    • Anatomical structure: thymus

    • Anatomical structure: testis

    • Anatomical structure: brain

    • Anatomical structure: kidney

    • Anatomical structure: small_intestine

    • Anatomical structure: heart

    • Anatomical structure: placenta

    • Anatomical structure: lung

    • Anatomical structure: pancreas

    • Anatomical structure: prostate

    • Anatomical structure: killer_cell

      • IL-2 activated NK cells secrete soluble CD100. [6]

      Influenced by:

      • CD72
        in dendritic_cell_in_lymphoid_tissues
        • Activated NK cells express CD100 and produce soluble CD100. They interact with dentritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [6]
      • CD72
        in macrophage
        • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [6]
    • Anatomical structure: B-lymphocyte

      • The generation of soluble CD100/Sema4D appears to be well regulated; its release from primary B cells is strictly dependent on a proteolytic cascade that follows cellular activation [7]
    • Anatomical structure: T-lymphocyte

      • The generation of soluble CD100/Sema4D appears to be well regulated; its release from primary T cells is strictly dependent on a proteolytic cascade that follows cellular activation [7]
    • Anatomical structure: monocyte

    Targets

    CellCD72hepatocyte growth factor receptorPLXNB1PLXNB2
    B-lymphocyte Present
    Phenotypes
    • B cell response/activation
    • monocyte activation
    brain Present
    Phenotypes
    • axon guidance
    colon Present
    continuous vascular endothelial cell of blood vessels and lymphatics Present
    Phenotypes
    • positive regulation of cell growth
    dendritic cell in lymphoid tissues Present
    Influences
    • IFN-gamma
    • SEMA4D
    digestive system Present
    epithelial cell Present
    Phenotypes
    • branching morphogenesis
    • positive regulation of cell growth
    fetal brain Present
    fetal kidney Present
    hepatocyte Present
    Present
    hippocampus Present
    Phenotypes
    • axon guidance
    kidney Present
    Present
    macrophage Present
    Phenotypes
    • macrophage activation during immune response
    Influences
    • IFN-gamma
    • SEMA4D
    neuron Present
    pancreas Present
    placenta Present
    prolymphocyte Present
    retina Present
    small intestine Present
    spleen Present
    stomach Present
    thyroid gland Present
    umbilical vein endothelial cells Present
    vascularendothelial cell Present
    Reference