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Details for messenger / hormone: fas Ligand

EndoNet ID: ENH00583

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Synonyms

  • fas Ligand
  • TNFSF6
  • CD95L
  • apo I Ligand
  • APTL

General information

  • Function: Fas Ligand binds to the Fas receptor, which is one of the most common death receptor, thus inducing apoptotic pathways. [1]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TNF family

      Links to other resources

      • Anatomical structure: lipocyte_of_liver

        • CD95 (APO-1/Fas) and CD95L (APO-1-/Fas-ligand) became increasingly expressed during the course of HSC activation. [2]
      • Anatomical structure: T-lymphocyte

      Targets

      Cellfas receptor
      cholangiocyte Present
      hepatocyte Present
      Kupffer cell stellate cell of liver Present
      lipocyte of liver Present
      Phenotypes
      • negative regulation of apoptosis
      sinusoidal endothelial cell Present
      Reference