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Details for messenger / hormone: IL-17D

EndoNet ID: ENH00585

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Synonyms

  • IL-17D
  • interleukin-17D
  • interleukin-27
  • IL-27
  • IL17D
  • IL-22
  • IL27
  • IL-27 p28 subunit

General information

  • IL-!7 is a family of cytokines with a high conservation at the c-terminal part of the protein, while the N-terminal is changed. IL-17D stimulates the production of IL-6, IL-8 and GM-CSF and have also the abillity of inhibiting hemopoiesis of myeloid progenitor cells in colony formimg assays. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-17 family

      Composition

      Sequence 
      MLVAGFLLA LPPSWAAGA PRAGRRPAR 
PRGCADRPE ELLEQLYGR LAAGVLSAF 
HHTLQLGPR EQARNASCP AGGRPADRR 
FRPPTNLRS VSPWAYRIS YDPARYPRY 
LPEAYCLCR GCLTGLFGE EDVRFRSAP 
VYMPTVVLR RTPACAGGR SVYTEAYVT 
IPVGCTCVP EPEKDADSI NSSIDKQGA 
KLLLGPNDA PAGP

      Links to other resources

      UniProt Q8TAD2
      Ensembl ENST00000304920
      KEGG hsa:53342

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: pancreas

      • Anatomical structure: adipose_tissue

      • Anatomical structure: heart

      • Anatomical structure: lung

      • Anatomical structure: brain

      Targets

      CellTCCR
      B-lymphocyte Present
      leukocyte Present
      lymph node Present
      monocyte Present
      peripheral blood leukocytes Present
      spleen Present
      T-lymphocyte Present
      Reference