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Details for messenger / hormone: LTE4

EndoNet ID: ENH00590

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Synonyms

  • LTE4
  • leukotriene E4
  • cysteinyl leukotriene E4
  • 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid

General information

  • LTE4 increases the uptake of intravenously injected methotrexate about twofolds within the tumor, but not in the normal brain tissue. [1]
  • LTE4 is implicated in asthma pathophysiology and as one of the causes of persistent bronchoconstriction and mucus hypersecretion in chronic obstructive pulmonary disease (COPD). [2]

Classification

Hormone function

  • homeostasis
    • pulmonary control

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • leukotrienes

      Composition

      Links to other resources

      KEGG C05952
      LIPID MAPS LMFA03020002
      LipidBank XPR3401

        Targets

        CellCysLTR1CysLTR2
        adrenal gland Present
        colon Present
        heart Present
        		Present
        lung Present
        		Present
        pancreas Present
        peripheral blood leukocytes Present
        		Present
        placenta Present
        		Present
        small intestine Present
        smooth muscle Present
        spleen Present
        		Present
        Reference