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Details for messenger / hormone: NPS

EndoNet ID: ENH00592

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Synonyms

  • NPS
  • neuropeptide S

General information

  • Neuropeptide S is the endogenous ligand for the previous orphan G-protein-coupled receptor GPR154, now referred to as the NPS receptor (NPSR). [1]
  • Modulator of wakefulness and anxiety.
  • NPS is capable of inducing phagocytosis of unopsonized bacteria. [2]
  • Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses. [2]
  • Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. [3]

Classification

Hormone function

  • CNS function
    • mood / behaviour
      • stress response

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters

      Composition

      unprocessed precursor

      Sequence
      MISSVKLNL ILVLSLSTM HVFWCYPVP 
      SSKVSGKSD YFLILLNSC PTRLDRSKE 
      LAFLKPILE KMFVKRSFR NGVGTGMKK 
      TSFQRAKS

      Links to other resources

      UniProt P0C0P6
      Ensembl ENST00000398023
      KEGG hsa:594857
      • Anatomical structure: brain

        • Prepro-NPS mRNA is expressed discretely in a few brain areas, with strongest expression in the peri-locus ceruleus, principle sensory 5 nucleus, and the lateral parabrachial nucleus of the brainstem. [4]

      Targets

      CellNPSR1
      amygdaloid body Present
      Phenotypes
      • attenuation of anxiety behavior
      cerebral cortex Present
      hypothalamus Present
      thalamus Present
      Phenotypes
      • arousal
      Reference