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Details for messenger / hormone: NPAF

EndoNet ID: ENH00595

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Synonyms

  • FMRFamide-related peptides
  • NPAF
  • neuropeptide AF

General information

  • Neuropeptides FF (NPFF), AF (NPAF), and SF (NPSF) are homologous amidated peptides encoded by the same precursor mRNA. [1]
  • Neuropeptides FF (NPFF) and AF (NPAF) are involved in pain modulation and opioid tolerance. [2]
  • Involved in pain regulation. [1]

Classification

Hormone function

  • CNS function
    • pain

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • FaRP family

      Composition

      Sequence
      AGEGLNSQF WSLAAPQRF

      Links to other resources

      UniProt O15130
      Ensembl ENST00000267017
      KEGG hsa:8620

        Targets

        CellNPFF-R1NPFF-R2
        hypothalamus Present
        Influences
        • GnRH-I
        pituitary gland of diencephalon Present
        Influences
        • FSH
        • LH
        Reference