Status
Please wait ...

Details for messenger / hormone: RFRP-3

EndoNet ID: ENH00598

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • neuropeptide RFRP-1
  • neuropeptide VF
  • FMRFamide-related peptides
  • RFRP-3
  • neuropeptide RFRP-3
  • neuropeptide NPVF
  • FaRP3
  • RFamide-related peptide 3

General information

  • FMRFamide-related peptide.
  • RFamide-related peptides are potentially involved in pain regulation through a hypothalamo-medullary projection system, and possibly via action on neuropeptide FF 2 receptors. [1]
  • The RFamide-related peptide gene, C7orf9, which encodes a precursor protein for at least two small neuropeptides, referred to as NPSF (alias RFRP-1) and NPVF (alias RFRP-3), is abundantly expressed in the human retina. [2]
  • FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. [3]

Classification

Hormone function

  • CNS function
    • pain

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • FaRP family

      Composition

      Sequence
      VPNLPQRF

      Links to other resources

      UniProt Q9HCQ7
      Ensembl ENST00000222674
      KEGG hsa:64111

        Targets

        CellNPFF-R1
        hypothalamus Present
        Influences
        • GnRH-I
        pituitary gland of diencephalon Present
        Influences
        • FSH
        • LH
        Reference