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Details for messenger / hormone: RFRP-3

EndoNet ID: ENH00598

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  • neuropeptide RFRP-1
  • neuropeptide VF
  • FMRFamide-related peptides
  • RFRP-3
  • neuropeptide RFRP-3
  • neuropeptide NPVF
  • FaRP3
  • RFamide-related peptide 3

General information

  • FMRFamide-related peptide.
  • RFamide-related peptides are potentially involved in pain regulation through a hypothalamo-medullary projection system, and possibly via action on neuropeptide FF 2 receptors. [1]
  • The RFamide-related peptide gene, C7orf9, which encodes a precursor protein for at least two small neuropeptides, referred to as NPSF (alias RFRP-1) and NPVF (alias RFRP-3), is abundantly expressed in the human retina. [2]
  • FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. [3]


Hormone function

  • CNS function
    • pain

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • FaRP family



      Links to other resources

      UniProt Q9HCQ7
      Ensembl ENST00000222674
      KEGG hsa:64111


        hypothalamus Present
        • GnRH-I
        pituitary gland of diencephalon Present
        • FSH
        • LH