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Details for messenger / hormone: NPB23

EndoNet ID: ENH00599

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Synonyms

  • preproprotein L7
  • neuropeptide B
  • NPB23
  • neuropeptide B-23
  • hL7
  • PPNPB

General information

  • Widely expressed in the central nervous system, high levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain, lower levels in testis, uterus and ovary. [1]
  • Endogenous ligand on GPR7 and GPR8. [2]
  • Has a C-6-brominated tryptophan residue at the N terminus. [2]
  • Implicated in regulation of body weight. [3]
  • The two forms of NPB like NPW are produced from a single precursor gene by differential proteolytic processing at two arginine residues. [4]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • neuropeptide B/W family

      Composition

      Sequence 
      WYKPAAGHS SYSVGRAAG LLSGLR

      Links to other resources

      UniProt Q8NG41
      Ensembl ENST00000333383
      KEGG hsa:256933

      • Anatomical structure: substantia_nigra

      • Anatomical structure: hypothalamus

      • Anatomical structure: hippocampus

      • Anatomical structure: spinal_cord

      • Anatomical structure: placenta

      • Anatomical structure: testis

      • Anatomical structure: ovary

      • Anatomical structure: uterus

      Targets

      CellGPR7GPR8
      adenohypophysis Present
      amygdaloid body Present
      cerebellum Present
      frontal lobe Present
      hippocampus Present
      trachea Present
      Reference