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Details for messenger / hormone: NPW23

EndoNet ID: ENH00601

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Synonyms

  • preproprotein L8
  • neuropeptide W
  • NPW23
  • neuropeptide W-23
  • hL8

General information

  • NPW is produced in gastric antral G cells. [1]
  • Stimulates food intake and prolactin release. [2]
  • Implicated in regulation of body weight. [3]
  • The two forms of NPB like NPW are produced from a single precursor gene by differential proteolytic processing at two arginine residues. [4]
  • Neuropeptide W is a 30-amino-acid peptide, endogenous ligand for the G protein-coupled receptors GPR7 and GPR8. [1]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • neuropeptide B/W family

      Composition

      Sequence 
      WYKHVASPR YHTVGRAAG LLMGL

      Links to other resources

      UniProt Q8N729
      Ensembl ENST00000329610
      KEGG hsa:283869

      • Anatomical structure: mucosa_of_gastric_wall

      • Anatomical structure: stomach

      • Anatomical structure: hypothalamus

      Targets

      CellGPR7GPR8
      adenohypophysis Present
      amygdaloid body Present
      cerebellum Present
      frontal lobe Present
      hippocampus Present
      trachea Present
      Reference