Status
Please wait ...

Details for messenger / hormone: NPW30

EndoNet ID: ENH00602

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • NPW30
  • neuropeptide W-30
  • hL8C
  • neuropeptide W
  • preproprotein L8
  • hPPL8
  • NPW
  • PPL8
  • PPNPW

General information

  • Chronic infusion of NPW reduces body weight gain, suppresses food intake and increases body temperature, oxygen consumption and heat production. [1]
  • Implicated in regulation of body weight. [2]
  • NPW is produced in gastric antral G cells. [3]
  • Neuropeptide W is a 30-amino-acid peptide, endogenous ligand for the G protein-coupled receptors GPR7 and GPR8. [3]
  • The two forms of NPB like NPW are produced from a single precursor gene by differential proteolytic processing at two arginine residues. [1]

Classification

Hormone function

  • metabolism
    • cell metabolism
      • nutrient supply

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • neuropeptide B/W family

        Composition

        Neuropeptide W-30

        Sequence
        WYKHVASPR YHTVGRAAG LLMGLRRSP 
        YLW
        UniProt Q8N729

        Links to other resources

        UniProt Q8N729
        Ensembl ENST00000329610
        KEGG hsa:283869
        • Anatomical structure: mucosa_of_gastric_wall

        • Anatomical structure: stomach

        • Anatomical structure: hypothalamus

        Targets

        CellGPR7GPR8
        adenohypophysis Present
        amygdaloid body Present
        cerebellum Present
        frontal lobe Present
        hippocampus Present
        trachea Present
        Reference