Please wait ...

Details for messenger / hormone: NPW30

EndoNet ID: ENH00602

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • NPW30
  • neuropeptide W-30
  • hL8C
  • neuropeptide W
  • preproprotein L8
  • hPPL8
  • NPW
  • PPL8

General information

  • Chronic infusion of NPW reduces body weight gain, suppresses food intake and increases body temperature, oxygen consumption and heat production. [1]
  • Implicated in regulation of body weight. [2]
  • NPW is produced in gastric antral G cells. [3]
  • Neuropeptide W is a 30-amino-acid peptide, endogenous ligand for the G protein-coupled receptors GPR7 and GPR8. [3]
  • The two forms of NPB like NPW are produced from a single precursor gene by differential proteolytic processing at two arginine residues. [1]


Hormone function

  • metabolism
    • cell metabolism
      • nutrient supply

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • neuropeptide B/W family


        Neuropeptide W-30

        UniProt Q8N729

        Links to other resources

        UniProt Q8N729
        Ensembl ENST00000329610
        KEGG hsa:283869
        • Anatomical structure: mucosa_of_gastric_wall

        • Anatomical structure: stomach

        • Anatomical structure: hypothalamus


        adenohypophysis Present
        amygdaloid body Present
        cerebellum Present
        frontal lobe Present
        hippocampus Present
        trachea Present