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Details for messenger / hormone: apelin-13

EndoNet ID: ENH00613

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  • APJ endogenous ligand
  • Apelin
  • apelin-13
  • APJ endogenous ligand 13

General information

  • Apelin-13 plays an important role in the regulation of behavioral, endocrine and homeostatic responses in the human central nervous system. [1]
  • Apelin-13 represses the activity of APJ as a HIV-1 coreceptor,the interaction betweenapelin-13 and the APJ receptor is critical for further investigation of apelin-APJ functions. [2]
  • Inhibits the human immunodeficiency virus type I (HIV-1) entry in cells coexpressing CD4 and APJ. [3]


Hormone function

  • CNS function
    • mood / behaviour

    Chemical classification

    • hormone
      • genome-encoded
        • apelins




      Links to other resources

      UniProt Q9ULZ1
      Ensembl ENST00000307484
      KEGG hsa:8862
      • Anatomical structure: frontal_lobe

      • Anatomical structure: hypothalamus

      • Anatomical structure: thalamus

      • Anatomical structure: periventricular_nucleus_of_hypothalamus

      • Anatomical structure: adipose_tissue