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Details for messenger / hormone: endothelin-2

EndoNet ID: ENH00619

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Synonyms

  • Preproendothelin-2
  • endothelin-2
  • endothelin 2
  • ET-2
  • ET2

General information

  • Vasoactive peptide.
  • Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. [1]
  • Macrophage chemoattractant. [2]
  • Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • cancer / metastasis

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • endothelins

        Composition

        Sequence
        CSCSSWLDK ECVYFCHLD IIW

        Links to other resources

        UniProt P20800
        Ensembl ENST00000372587
        KEGG hsa:1907
        • Anatomical structure: lung

        • Anatomical structure: digestive_system

          • Endothelin (ET)-2, an ET family peptide, is highly expressed in intestine. [4]

        Targets

        CellETA-RETB-R
        bergmann glia Present
        chief cell of parathyroid gland Present
        Influences
        • PTH
        Present
        Influences
        • PTH
        lipocyte of liver Present
        Phenotypes
        • actin-mediated cell contraction
        Present
        Phenotypes
        • actin-mediated cell contraction
        Reference