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Details for messenger / hormone: endothelin-3

EndoNet ID: ENH00620

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Synonyms

  • endothelin-3
  • ET-3
  • preproendothelin-3
  • PPET3
  • EDN3
  • endothelin 3
  • ET3

General information

  • Endothelin-3 and its inactive precursor, big endothelin-3, are both found in human plasma. [1]
  • 3 isoforms at NCBI: NP_996917, NP_996915, NP_996916.
  • Vasoactive peptide.
  • Promotes migration of endothelial cells. [2]
  • The Kell blood group protein is a proteolytic enzyme that processes big ET-3, generating ET-3, a potent bioactive peptide with multiple biological roles. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • growth stimulation

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • endothelins

        Composition

        Sequence
        CTCFTYKDK ECVYYCHLD IIW

        Links to other resources

        UniProt P14138
        Ensembl ENST00000371028
        KEGG hsa:1908

          Targets

          CellETA-RETB-R
          bergmann glia Present
          chief cell of parathyroid gland Present
          Influences
          • PTH
          Present
          Influences
          • PTH
          lipocyte of liver Present
          Phenotypes
          • actin-mediated cell contraction
          Present
          Phenotypes
          • actin-mediated cell contraction
          Reference