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Details for messenger / hormone: neurokinin A

EndoNet ID: ENH00621

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Synonyms

  • PPT
  • Protachykinin-1
  • neurokinin A
  • NKA
  • substance K
  • neuromedin L
  • SK

General information

  • The anti-proliferative effect of neurokinin-A on hematopoietic progenitor cells is partly mediated by p53 activating the 5' flanking region of neurokinin-2 receptor. [1]
  • Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects. [2]
  • Neurokinin A is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. [3]
  • Neurokinin A acts via a receptor (the NK-2 receptor) believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. [3]

Classification

Hormone function

  • homeostasis
    • pulmonary control
    • development and growth
      • growth inhibition

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • tachykinins

        Composition

        Sequence
        HKTDSFVGL M
        UniProt P20366-1

        Links to other resources

        UniProt P20366
        Ensembl ENST00000319273
        KEGG hsa:6863

          Targets

          Cellneurokinin-2 receptorNK-3RSPR
          corpus striatum Present
          Phenotypes
          • sensory perception of pain
          Reference