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Details for messenger / hormone: C-type natriuretic peptide

EndoNet ID: ENH00628

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Synonyms

  • C-type natriuretic peptide
  • NPPC
  • CNP

General information

  • CNP, found in endothelial cells, chondrocytes, and neurons, binds its cognate transmembrane receptor, natriuretic peptide receptor-B, and stimulates the synthesis of the intracellular signaling molecule, cGMP. [1]
  • C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. [2]
  • C-type natriuretic peptide is the major natriuretic peptide in human cerebrospinal fluid. [3]
  • CNP is a vasodilator produced by the vascular endothelium. [4]
  • Vasorelaxant and cGMP-stimulating activity. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • natriuretic peptides

      Composition

      CNP-22

      • Human proCNP contains 103 residues, and the intracellular endoprotease furin has been shown to process proCNP to the mature 53-amino-acid peptide in vitro. In some tissues, CNP-53 is cleaved to CNP-22 by an unknown extracellular enzyme. CNP-22 and CNP-53 elicit similar if not identical functions. [6]
      Sequence
      GLSKGCFGL KLDRIGSMS GLGC

      CNP-29

      Sequence
      YKGANKKGL SKGCFGLKL DRIGSMSGL 
      GC

      CNP-53

      Sequence
      DLRVDTKSR AAWARLLQE HPNARKYKG 
      ANKKGLSKG CFGLKLDRI GSMSGLGC

      Links to other resources

      UniProt P23582
      Ensembl ENST00000409852
      KEGG hsa:4880
      • Anatomical structure: brain

        • CNP is the most highly expressed natriuretic peptide in the brain and is found in high concentrations in chondrocytes and cytokine-exposed endothelial cells. [6]
      • Anatomical structure: chondrocyte

      • Anatomical structure: endothelial_cell

      Targets

      CellNPR2
      chondrocyte Present
      Phenotypes
      • long bone growth
      smooth muscle cell Present
      Phenotypes
      • vascular relaxation
      Reference