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Details for messenger / hormone: BNP-32

EndoNet ID: ENH00631

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Synonyms

  • gamma-brain natriuretic peptide
  • natriuretic peptides B
  • BNP-32
  • brain natriuretic peptide 32
  • BNP32

General information

  • C-terminal brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for the diagnosis, prognosis, and treatment of heart failure. [1]
  • The 32-aa peptide is synthesized primarily in the atrial and ventricular myocardium and constitutes the mature biologically active form of immature BNP (pro-BNP). [1]
  • Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. [2]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
      • ion flow control
        • further hormone secretion

        Chemical classification

        • hormone
          • genome-encoded
            • natriuretic peptides

          Composition

          Brain natriuretic peptide 32

          • Human BNP is synthesized as a preprohormone of 134 residues containing a signal sequence that is cleaved to yield a 108-amino-acid prohormone (Fig. 1⇑). Additional cleavage by an unknown protease results in an inactive 76-residue amino-terminal (nt) fragment and a 32-residue carboxyl-terminal biologically active peptide. [3]
          Sequence 
          SPKMVQGSG CFGRKMDRI SSSSGLGCK 
VLRRH

          Links to other resources

          UniProt P16860
          Ensembl ENST00000376468
          KEGG hsa:4879

          • Anatomical structure: ventricles

            • Ventricular BNP production is transcriptionally regulated by cardiac wall stretch resulting from volume overload. [3]

          Targets

          CellNPR1
          adrenal cortex Present
          Influences
          • ↓ aldosterone
          kidney Present
          Phenotypes
          • natriuresis
          • diuresis
          Influences
          • ↓ renin
          lung Present
          Phenotypes
          • dilation of pulmonary airways
          smooth muscle cell Present
          Phenotypes
          • vascular relaxation
          Reference