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Details for messenger / hormone: TIMP-1

EndoNet ID: ENH00633

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Synonyms

  • erythroid-potentiating activity
  • tissue inhibitor of metalloproteinases 1
  • TIMP-1
  • tissue inhibitor of metalloproteinase 1
  • metalloproteinase inhibitor 1
  • erythroid potentiating activity
  • EPA
  • fibroblast collagenase inhibitor
  • collagenase inhibitor
  • CLGI
  • TIMP1
  • TIMP
  • TIMP 1

General information

  • Inhibits matrix metalloproteases.
  • Forms a complex with MMP9 at cell surface.
  • TIMP-1-mediated cell cycle arrest is associated with its downregulation of cyclin D(1) and upregulation of p27(KIP1), resulting in inhibition of cyclin-dependent kinase activity necessary for phosphorylation of the tumor suppressor retinoblastoma protein. [1]
  • Contributes to cell proliferation and stress responses.
  • TIMP-1 has antiapoptotic activity. [1]
  • Subject to X chromosomal inactivation.
  • Acts on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. [2]
  • Overexpression of TIMP-1 correlates with aggressive clinical behavior of a spectrum of tumors. [3]
  • Erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt. [4]

Classification

Hormone function

  • CNS function
    • stress response
    • development and growth
      • growth stimulation

      Chemical classification

      Composition

      metalloproteinase inhibitor 1, chain

      Sequence 
      CTCVPPHPQ TAFCNSDLV IRAKFVGTP 
EVNQTTLYQ RYEIKMTKM YKGFQALGD 
AADIRFVYT PAMESVCGY FHRSHNRSE 
EFLIAGKLQ DGLLHITTC SFVAPWNSL 
SLAQRRGFT KTYTVGCEE CTVFPCLSI 
PCKLQSGTH CLWTDQLLQ GSEKGFQSR 
HLACLPREP GLCTWQSLR SQIA
      UniProt P01033

      TIMP1 mature peptide

      Sequence 
      CTCVPPHPQ TAFCNSDLV IRAKFVGTP 
EVNQTTLYQ RYEIKMTKM YKGFQALGD 
AADIRFVYT PAMESVCGY FHRSHNRSE 
EFLIAGKLQ DGLLHITTC SFVAPWNSL 
SLAQRRGFT KTYTVGCEE CTVFPCLSI 
PCKLQSGTH CLWTDQLLQ GSEKGFQSR 
HLACLPREP GLCTWQSLR SQIA

      Links to other resources

      UniProt P01033
      Ensembl ENST00000218388
      KEGG hsa:7076

      • Anatomical structure: macrophage

      Targets

      Cell
      No records found.
      Reference