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Details for messenger / hormone: TIMP-4

EndoNet ID: ENH00636

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Synonyms

  • tissue inhibitor of metalloproteinases 4
  • TIMP-4
  • tissue inhibitor of metalloproteinase 4
  • tissue inhibitor of metalloproteinases-4
  • TIMP metallopeptidase inhibitor 4
  • metalloproteinase inhibitor 4
  • TIMP4

General information

  • Inactivates MMP-1, MMP-2, MMP-3, MMP-7, MMP-9 and MMP-26.
  • TIMP-4 is the major intraplatelet MMP inhibitor and it is involved in regulation of platelet aggregation and recruitment. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    TIMP-4 (mature peptide)

    Sequence 
    EACSCAPAH PQQHICHSA LVIRAKISS 
EKVVPASAD PADTEKMLR YEIKQIKMF 
KGFEKVKDV QYIYTPFDS SLCGVKLEA 
NSQKQYLLT GQVLSDGKV FIHLCNYIE 
PWEDLSLVQ RESLNHHYH LNCGCQITT 
CYTVPCTIS APNECLWTD WLLERKLYG 
YQAQHYVCM KHVDGTCSW YRGHLPLRK 
EFVDIVQP
    UniProt Q99727

    Links to other resources

    UniProt Q99727
    Ensembl ENST00000287814
    KEGG hsa:7079

    • Anatomical structure: heart

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: cell_of_endometrium_of_uterus

    Targets

    Cell
    No records found.
    Reference